Author(s):
Jorge, Paula ; Pérez-Pérez, Martín ; Rodríguez, Gael Pérez ; Fdez-Riverola, Florentino ; Pereira, Maria Olívia ; Lourenço, Anália
Date: 2016
Persistent ID: http://hdl.handle.net/1822/52717
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/EC/FP7/316265/EU;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113196/PT
;
info:eu-repo/grantAgreement/FCT/3599-PPCDT/132966/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/126270/PT;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88192%2F2012/PT;
Subject(s): antimicrobial combination; antimicrobial peptide; combination network; infection; Pseudomonas aeruginosa; text mining; Science & Technology
Description
The combination of antimicrobial products is a promising biomedical strategy against the ever growing number of resistant strains emerging in healthcare and community settings. Agents with alternative modes of action, such as antimicrobial peptides (AMPs), and the efficacy of combined actions are being evaluated. Despite the availability of various antimicrobial data repositories, a wealth of information remains scattered through the scientific literature. This work introduces the automated curation pipeline implemented to produce the first ever network reconstruction of AMP-drug combinations. This network relates to antimicrobial combinations experimentally tested against Pseudomonas aeruginosa infections and includes 239 combinations among AMPs and other antimicrobials. The aim is to provide a global view of available interaction data and help design new antimicrobial studies. Reconstruction is on-going, coping with new experimental results for P. aeruginosa, and will be soon extended to other meaningful microbial pathogens. The network is publicly accessible at http://sing.ei.uvigo.es/antimicrobialCombination/.
The research leading to these results has received funding from: the European Union's Seventh Framework Programme FP7/REGPOT-2012-2013.1 under grant agreement n° 316265, BIOCAPS; FCT through the project AntiPep PTDC/SAU-SAP/113196/2009/FCOMP-01-0124-FEDER016012; the Strategic Project PEst-OE/EQB/LA0023/2013; the Project “BioHealth - Biotechnology and Bioengineering approaches to improve health quality", NORTE-07-0124FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER; the project “RECI/BBB-EBI/0179/2012 - Consolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB”, FCOMP-01-0124-FEDER027462; and the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273). This document reflects only the author’s views and the European Union is not liable for any use that may be made of the information contained herein. The authors also acknowledge the Foundation for Science and Technology (FCT) for the PhD Grant of Paula Jorge, Ref. SFRH/BD/88192/2012. The authors do not have any conflicts of interest.
info:eu-repo/semantics/publishedVersion
