Characterization of NS5A and NS5B resistance-associated substitutions from genotype 1 HCV infected patients in a Portuguese cohort

• Autor(es): Brandão, Ruben Alexandre Ribeiro
• Data: 2018
• Identificador Persistente: http://hdl.handle.net/10362/114993
• Origem: Repositório Institucional da UNL
• Assunto(s): Hepatitis C virus; Direct-acting antivirals
• Tipo de Documento: Dissertação de mestrado
• Idioma: Inglês
• Contribuidor(es): RUN

Descrição

"Hepatitis C virus (HCV) is considered to be the leading cause of hepatocellular carcinoma (HCC). During the last years, several highly efficacy regimens of direct-acting antivirals (DAAs) with excellent rates of success became available. However, therapeutic failure may occur in up to 10% of treated individuals. Our aim was to study the profile of NS5 coding region RASs in DAA-naive genotype 1 HCV infected patients, as well as to ascertain an association between treatment failure and the presence of baseline NS5 RASs. A comparison between LiPA and Sanger sequencing genotyping methods was also assessed.(...)"