Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    199,036.00 €

  • Start date

    2010-06-01

  • End date

    2013-05-31

Documents

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Myeloid Sirtuin 2 expression does not impact long-term Mycobacterium tuberculos...

Cardoso, Filipa; Castro, Flávia Raquel Teixeira de; Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; Torrado, Egídio

Sirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several transcription factors and enzymes. Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria monocytogenes infection. The impact of this molecule in the context of chronic infections remains unknown. We found that specific Sirt2 deletion in the myeloid lineage tran...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis o...

Cruz, Andrea; Ludovico, Paula; Torrado, Egídio; Gama, José B.; Sousa, Jeremy Nicolas Carvalho; Gaifem, Joana; Appelberg, Rui

The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to contro...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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Type I IFN inhibits alternative macrophage activation during mycobacterium tube...

Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, Flávia

Supplementary material: http://www.jimmunol.org/content/suppl/2016/11/12/jimmunol.1600584.DCSupplemental; Tuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In this artic...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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