Project/scholarship details
- Project/scholarship ID
102776
- Reference
PTDC/BIA-BCM/102776/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
173,388.00 €
- Start date
2010-06-01
- End date
2013-05-31
Documents
TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell ...
Coelho, Maria Teixeira; Cruz, Andrea; Carmona, J. A.; Sousa, Carole Lara Veiga de; Pereira, Daniela Maria Ramos; Saraiva, Ana Laura; Veldhoen, MarcThe authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-pr...
Impact of differential TLR recognition of Mycobacterium tuberculosis strains fo...
Sousa, Jeremy Nicolas CarvalhoDissertação de Mestrado em Ciências da Saúde; Tuberculosis (TB) remains one of the major worldwide threats, with approximately one third of the world population infected with the causative agent of this disease, Mycobacterium tuberculosis (Mtb). Recently developed genetic tools have showed the presence of a variety of Mtb lineages associated to the geographic distribution of the population. In our laboratory, w...
Myeloid Sirtuin 2 expression does not impact long-term Mycobacterium tuberculos...
Cardoso, Filipa; Castro, Flávia Raquel Teixeira de; Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; Torrado, EgídioSirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several transcription factors and enzymes. Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria monocytogenes infection. The impact of this molecule in the context of chronic infections remains unknown. We found that specific Sirt2 deletion in the myeloid lineage tran...
IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis o...
Cruz, Andrea; Ludovico, Paula; Torrado, Egídio; Gama, José B.; Sousa, Jeremy Nicolas Carvalho; Gaifem, Joana; Appelberg, RuiThe fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to contro...
Type I IFN inhibits alternative macrophage activation during mycobacterium tube...
Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, FláviaSupplementary material: http://www.jimmunol.org/content/suppl/2016/11/12/jimmunol.1600584.DCSupplemental; Tuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In this artic...
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