Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    40,000.00 €

  • Start date

    2010-04-01

  • End date

    2011-03-31

Documents

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Local Fetal Lung Renin-Angiotensin System as a Target to Treat Congenital Diaph...

Nogueira-Silva, C; Carvalho-Dias, E; Piairo, P; Nunes, S; Baptista, MJ; Moura, RS; Correia-Pinto, J

Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT(1...

Date: 2011   |   Origin: Repositório Científico do Hospital de Braga
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The apelinergic system in the developing lung: expression and signaling

Piairo, P; Moura, RS; Nogueira-Silva, C; Correia-Pinto, J

Apelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into vascular, ocular and heart development. Additionally, it is highly expressed in pulmonary tissue. Therefore, the aim of this study was to investigate the role o...

Date: 2011   |   Origin: Repositório Científico do Hospital de Braga
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The apelinergic system in the developing lung: expression and signaling

Piairo, Paulina C.; Moura, Rute S.; Silva, Cristina Nogueira; Pinto, Jorge Correia

Apelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into vascular, ocular and heart development. Additionally, it is highly expressed in pulmonary tissue. Therefore, the aim of this study was to investigate the role o...

Date: 2011   |   Origin: RepositóriUM - Universidade do Minho
More info.

Local fetal lung renin-angiotensin system as a target to treat congenital diaph...

Silva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C.; Nunes, Susana; Baptista, Maria João Ribeiro Leite; Moura, Rute S.

Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...

Date: 2012   |   Origin: RepositóriUM - Universidade do Minho
More info.

Leukemia inhibitory factor in rat fetal lung development: expression and functi...

Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Peixoto, Francisca; Moura, Rute S.; Pinto, Jorge Correia

Conceived and designed the experiments: CN-S EC-D JC-P. Performed the experiments: CN-S PP EC-D FOP RSM. Analyzed the data: CN-S PP JC-P. Wrote the paper: CN-S PP RSM JC-P.; Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional redu...

Date: 2012   |   Origin: RepositóriUM - Universidade do Minho
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The role of glycoprotein 130 family of cytokines in fetal rat lung development

Nogueira-Silva, C; Piairo, P; Carvalho-Dias, E; Veiga, C; Moura, RS; Correia-Pinto, J

The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching....

Date: 2013   |   Origin: Repositório Científico do Hospital de Braga
More info.

The role of glycoprotein 130 family of cytokines in fetal rat lung development

Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Veiga, Carla; Moura, Rute S.; Pinto, Jorge Correia

The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching...

Date: 2013   |   Origin: RepositóriUM - Universidade do Minho
More info.
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