108056
PTDC/SAU-FCF/108056/2008
FCT - Fundação para a Ciência e a Tecnologia, I.P.
Portugal
5876-PPCDTI
199,999.00 €
2010-02-05
2013-08-04
Tese de doutoramento em Ciências da Saúde, ramo Ciências Biomédicas apresentada à Faculdade de Medicina da Universidade de Coimbra; Huntington’s disease (HD) is a neurodegenerative disorder that gradually affects memory, cognitive skills and normal movements of the affected individuals and for which no disease modifying treatments exist. The disease is caused by an expanded CAG trinucleotide repeat (of variable...
Transcriptional deregulation and changes in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been described in Huntington's disease (HD). We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A and sodium butyrate (SB) ameliorate mitochondrial function in cells expressing mutant huntingtin. In this work, we investigated the effect of HDACIs on th...
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