114523
PTDC/EBB-BIO/114523/2009
FCT - Fundação para a Ciência e a Tecnologia, I.P.
Portugal
5876-PPCDTI
188,726.00 €
2011-01-01
2013-12-31
Tese de doutoramento em Engenharia Biomédica; Advances in self-assembly offer new opportunities in molecular design of biomaterials. A major advantage of these systems is their ability to generate similar fibrillar structures to those found in the natural extracellular matrix (ECM) of tissues and to integrate directly into their structure biomolecular ligands for cell signalling. On the other hand, the integrat...
Programa Doutoral em Engenharia dos Tecidos, Medicina Regenerativa e Células Estaminais.; The exquisite field of molecular self-assembly (SA) offers numerous opportunities to fabricate biomaterials with increased level of precision and complexity. Peptide molecules have been widely used as building blocks in biomaterial SA as they provide the possibility to form nanofibers that resemble the filamentous structur...
Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non-equilibrium for substantial periods of time. The system enabl...
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).; The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo app...
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