Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    599,997.00 €

  • Start date

    2012-01-01

  • End date

    2015-06-30

Documents

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IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis o...

Cruz, Andrea; Ludovico, Paula; Torrado, Egídio; Gama, José B.; Sousa, Jeremy Nicolas Carvalho; Gaifem, Joana; Appelberg, Rui

The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to contro...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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Lack of the transcription factor hypoxia-inducible factor (HIF)-1α in macrophag...

Cardoso, Marcos S.; Silva, Tânia M.; Resende, Mariana; Appelberg, Rui; Borges, Margarida

Accepted Manuscript; The establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune response to a limited area. In some cases these lesions can grow progressively into large granulom...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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