Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    137,760.00 €

  • Start date

    2013-07-01

  • End date

    2015-08-31

Documents

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What should be considered in the treatment of bacterial infections by multi-dru...

Pimenta, Francisco; Abreu, Ana Cristina; Simões, Lúcia C.; Simões, M.

Bacterial infections are a global health concern with high levels of mortality and morbidity associated. The resistance of pathogens to drugs is one leading cause of this problem, being common the administration of multiple drugs to improve the therapeutic effects. This review critically explores diverse aspects involved in the treatment of bacterial infections through multi-drug therapies, from a mathematical ...

Date: 2014   |   Origin: RepositóriUM - Universidade do Minho
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Combinatorial activity of flavonoids with antibiotics against drug resistant St...

Abreu, Ana Cristina; Serra, Sofia Cravino; Borges, Anabela; Saavedra, Maria J.; Mcbain, Andrew J.; Salgado, A. J.; Simões, Manuel

The use of resistance-modifying agents is a potential strategy that is used to prolong the effective life of antibiotics in the face of increasing antibiotic resistance. Since certain flavonoids are potent bacterial efflux pump inhibitors, we assessed morin, rutin, quercetin, hesperidin, and (+)-catechin for their combined activity with the antibiotics ciprofloxacin, tetracycline, erythromycin, oxacillin, and a...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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Antibacterial activity and mode of action of selected glucosinolate hydrolysis ...

Borges, Anabela; Abreu, Ana C.; Ferreira, Carla; Saavedra, Maria J.; Simões, Lúcia C.; Simões, Manuel

Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial agents in food industry. The aim of this study was to assess the antibacterial activity of two isothiocyanates (ITCs), allylisothiocyanate (AITC) and 2-phenylethyl...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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