70895
PTDC/SAU-MII/70895/2006
FCT - Fundação para a Ciência e a Tecnologia, I.P.
Portugal
5876-PPCDTI
116,774.00 €
2007-07-09
2010-07-08
Dissertação de mestrado em Genética Molecular; Effective control of Mycobacterium tuberculosis infection requires the induction of inflammatory T helper (Th) 1 responses and avoidance of tissue damage. However, little is known about the mechanisms that rule the fine balance between protection and pathology in this infection. The anti-inflammatory cytokine IL-10 is important for the regulation of the immune resp...
The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-pr...
Tese de Doutoramento Ciências da Saúde – Ciências da Saúde; The early immune recognition of mycobacteria is of most importance for the initiation of microbicidal mechanisms and modulation of adaptive immune responses. Macrophages and dendritic cells (DCs) are important players of the innate immune response and are among the first cells to sense mycobacteria. This initial recognition of the pathogen is only poss...
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