Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    96,471.00 €

  • Start date

    2007-07-01

  • End date

    2010-06-30

Documents

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The stressed prefrontal cortex. Left? Right!

Cerqueira, João José; Almeida, Osborne F. X.; Sousa, Nuno

The prefrontal cortex (PFC) plays an important role in the integration of cognitive and affective behavior and regulating autonomic and neuroendocrine functions. This region of the brain, which may be considered analogous to the RAM memory of a computer, is important for translating stressful experience into adaptive behavior. The PFC responds to stress and modulates the response to stress through regulation of...

Date: 2008   |   Origin: RepositóriUM - Universidade do Minho
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The mood-improving actions of antidepressants do not depend on neurogenesis but...

Bessa, J. M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, João José; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, Nuno

The mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis and amelioration of depressive symptoms have gained currency over the years although the original evidence has been challenged. In this study, an unpredictable chronic mild stress protocol was used to induce a depressive-...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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Interleukin-10: a key cytokine in depression?

Roque, Susana; Neves, Margarida Correia; Mesquita, Ana Raquel Marcelino; Palha, Joana Almeida; Sousa, Nuno

An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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