Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    POCI

  • Funding amount

    80,000.00 €

  • Start date

    2005-07-01

  • End date

    2008-12-30

Documents

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Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel met...

Carvalho, A; Marques, A; Maciel, P; Rodrigues, F

Toll-like receptors (TLRs) are cellular receptors that mediate recognition of microbial challenges and the subsequent inflammatory response. Genetic variations within these inflammation-associated genes may alter host-pathogen defence mechanisms affecting susceptibility towards infectious diseases. Taking into account the significance of these genes, we developed a simple and rapid method based in the bi-direct...

Date: 2007   |   Origin: Repositório Científico do Hospital de Braga
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Multiplex PCR identification of eight clinically relevant Candida species

Carvalho, Agostinho; Oliveira, Sofia Costa de; Martins, M. L.; Pina-Vaz, C.; Rodrigues, A. G.; Ludovico, Paula; Rodrigues, Fernando José dos Santos

Invasive fungal infections, specifically candidemia, constitute major public health problems with high mortality rates. Therefore, in the last few years, the development of novel diagnostic methods has been considered a critical issue. Herein we describe a multiplex PCR strategy allowing the identification of 8 clinically relevant yeasts of the Candida genus, namely C. albicans, C. glabrata, C. parapsilosis, C....

Date: 2007   |   Origin: RepositóriUM - Universidade do Minho
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Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel met...

Carvalho, Agostinho; Marques, A.; Maciel, P.; Rodrigues, Fernando José dos Santos

Toll-like receptors (TLRs) are cellular receptors that mediate recognition of microbial challenges and the subsequent inflammatory response. Genetic variations within these inflammation-associated genes may alter host-pathogen defence mechanisms affecting susceptibility towards infectious diseases. Taking into account the significance of these genes, we developed a simple and rapid method based in the bi-direct...

Date: 2007   |   Origin: RepositóriUM - Universidade do Minho
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Polymorphisms in toll-like receptor genes and susceptibility to pulmonary asper...

Carvalho, Agostinho; Pasqualotto, A. C.; Pitzurra, L.; Romani, L; Denning, D. W.; Rodrigues, Fernando José dos Santos

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bron...

Date: 2008   |   Origin: RepositóriUM - Universidade do Minho
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T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in ...

Carvalho, Agostinho; Santos, M.; Maciel, P.; Rodrigues, Fernando José dos Santos

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an associ...

Date: 2008   |   Origin: RepositóriUM - Universidade do Minho
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Polymorphisms in Toll-like receptor genes and susceptibility to infections in a...

Carvalho, Agostinho; Cunha, Cristina; Carotti, Alessandra; Aloisi, Teresa; Guarrera, Ornella; Di Ianni, Mauro; Falzetti, Franca; Bistoni, Francesco

Objective Discovery of genetic variations in the genes encoding for Toll-like receptors (TLRs) has highlighted a potential link between genomic variation of the host and susceptibility to infections. Materials and Methods We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes in recipients of allogeneic hematopoietic stem cell transplant and susceptibility to infections caused b...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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