Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    173,000.00 €

  • Start date

    Tue Mar 01 00:00:00 WET 2011

  • End date

    Mon Jun 30 00:00:00 WEST 2014

  • Date awarded

    Wed Dec 22 00:00:00 WET 2010

Documents


Mitochondrial DNA signals of Late Glacial recolonization of Europe from Near Ea...

Pala, M; Olivieri, A; Achilli, A; Accetturo, M; Metspalu, E; Reidla, M; Tamm, E; Karmin, M; Reisberg, T; Hooshiar Kashani, B; Perego, UA; Carossa, V

Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and t...


The Arabian cradle: Mitochondrial relicts of the first steps along the southern...

Fernandes, V; Alshamali, F; Alves, M; Costa, MD; Pereira, JB; Silva, NM; Cherni, L; Harich, N; Cerny, V; Soares, P; Richards, MB; Pereira, L

A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first human steps outside of Africa. The "southern coastal route" model predicts that the early stages of the dispersal took place when people crossed the Red Sea to southern Arabia, but genetic evidence has hitherto been tenuous. We have addressed this question by analyzing the three mino...


Evaluating purifying selection in the mitochondrial DNA of various mammalian sp...

Soares, P; Abrantes, D; Rito, T; Thomson, N; Radivojac, P; Li, B; Macaulay, V; Samuels, DC; Pereira, L

Mitochondrial DNA (mtDNA), the circular DNA molecule inside the mitochondria of all eukaryotic cells, has been shown to be under the effect of purifying selection in several species. Traditional testing of purifying selection has been based simply on ratios of nonsynonymous to synonymous mutations, without considering the relative age of each mutation, which can be determined by phylogenetic analysis of this no...


The first modern human dispersals across Africa

Rito, T; Richards, MB; Fernandes, V; Alshamali, F; Cerny, V; Pereira, L; Soares, P

The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it feasible to test more sophisticated models of early modern human dispersals suggested by mtDNA distributions. Here we have generated 42 novel whole-mtDNA genomes belonging to haplogroup L0, the most divergent clade in the maternal line of desc...


Global human frequencies of predicted nuclear pathogenic variants and the role ...

Pereira, L; Soares, P; Triska, P; Rito, T; Waerden, Avd; Li, B; Radivojac, P; Samuels, DC

Mitochondrial proteins are coded by nuclear (nDNA) and mitochondrial (mtDNA) genes, implying a complex cross-talk between the two genomes. Here we investigated the diversity displayed in 104 nuclear-coded mitochondrial proteins from 1,092 individuals from the 1000 Genomes dataset, in order to evaluate if these genes are under the effects of purifying selection and how that selection compares with their mitochon...


Genetic stratigraphy of key demographic events in Arabia

Fernandes, V; Triska, P; Pereira, JB; Alshamali, F; Rito, T; Machado, A; Fajkosova, Z; Cavadas, B; Cerny, V; Soares, P; Richards, MB; Pereira, L

At the crossroads between Africa and Eurasia, Arabia is necessarily a melting pot, its peoples enriched by successive gene flow over the generations. Estimating the timing and impact of these multiple migrations are important steps in reconstructing the key demographic events in the human history. However, current methods based on genome-wide information identify admixture events inefficiently, tending to estim...

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