Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country


  • Funding program


  • Funding amount

    159,540.00 €

  • Start date

    Tue Jan 18 00:00:00 WET 2011

  • End date

    Thu Jul 17 00:00:00 WEST 2014

  • Date awarded

    Wed Dec 22 00:00:00 WET 2010


The role of Jagged1 in adult angiogenesis and in solid tumor development

Pedrosa, Ana Rita Ponce Álvares de Águeda

Jagged1 (Jag1) is a Notch signaling ligand, which has been described as essential for developmental angiogenesis and to play an important role in several aspects of tumor biology. However the underlying mechanism related to Jagged1/Notch signaling still remain incompletely understood. Therefore this thesis analyzed Jagged1 driven Notch signaling enrolment in adult angiogenesis settings, and in tumor development...

Date: 2016   |   Origin: Repositório da UTL

In vivo evaluation of the role of Delta-like 4/Notch signaling in the developme...

Badenes, Marina Martins

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death in the Western world. Dll4/Notch signaling has been shown to regulate tumor angiogenesis and cancer stem cell maintenance in CRC, but how it affects the intestinal precancerous lesions that lead to CRC initiation is not known. Therefore we evaluated the role of Dll4/Notch pathway during intestinal tu...

Date: 2016   |   Origin: Repositório da UTL


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