Project/scholarship details
- Project/scholarship ID
116627
- Reference
PTDC/SAU-TOX/116627/2010
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
3599-PPCDT
- Funding amount
176,563.00 €
- Start date
2012-02-01
- End date
2015-01-31
Documents
The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promotin...
Parada, Esther; Egea, Javier; Buendia, Izaskun; Negredo, Pilar; Cunha, Ana C.; Cardoso, Silvia; Soares, Miguel P.; López, Manuela G.The deposited article is a post-print version.; This deposit is composed by the main article, and it hasn't any supplementary materials associated.; This publication hasn't any creative commons license associated.; We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2...
Tissue damage control in disease tolerance
Soares, Miguel P; Gozzelino, Raffaella; Weis, SebastianThe deposited article is a prost-print version.; This publication hasn't any creative commons license associated.; This deposit is composed by the main article, and it hasn't any supplementary materials associated.; Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or amelio...
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation
Bolisetty, Subhashini; Zarjou, Abolfazl; Hull, Travis D.; Traylor, Amie M.; Perianayagam, Anjana; Joseph, Reny; Kamal, Ahmed I.; Arosio, PaoloThe deposited article is a post-print version (author's manuscript from PMC).; This publication hasn't any creative commons license associated.; The deposited article version contains attached the supplementary materials within the pdf.; Inflammation culminating in fibrosis contributes to progressive kidney disease. Cross-talk between the tubular epithelium and interstitial cells regulates inflammation by a coo...
Beyond killing: Can we find new ways to manage infection?
Vale, Pedro F.; McNally, Luke; Doeschl-Wilson, Andrea; King, Kayla C.; Popat, Roman; Domingo-Sananes, Maria R.; Allen, Judith E.; Soares, Miguel P.This deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication.; The antibiotic pipeline is running dry and infectious disease remains a major threat to public health. An efficient strategy to stay ahead of rapidly adapting pathogens should include approaches that replace, complement or enhance the effect of both current and novel antimicrobial compounds. ...
Red alert: labile heme is an alarmin
Soares, Miguel P; Bozza, Marcelo TThis publication hasn't any creative commons license associated.; This deposit is composed by the main article, and it hasn't any supplementary materials associated. There is no public supplementary material available.; The deposited article is a pre-print version.; Alarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule ...
IL-22 controls iron-dependent nutritional immunity against systemic bacterial i...
Sakamoto, Kei; Kim, Yun-Gi; Hara, Hideki; Kamada, Nobuhiko; Caballero-Flores, Gustavo; Tolosano, Emanuela; Soares, Miguel P.; Puente, José L.This publication hasn't any creative commons license associated.; This publication has a exclusive licensee of the American Association for the Advancement of Science.; The deposited article contains attached the supplementary materials.; Host immunity limits iron availability to pathogenic bacteria, but whether immunity limits pathogenic bacteria from accessing host heme, the major source of iron in the body, ...
Disease tolerance and immunity in host protection against infection
Soares, Miguel P.; Teixeira, Luis; Moita, Luis F.The deposited article is a pre-print version.; This publication hasn't any creative commons license associated.; This deposit is composed by the main article which contains attached the supplementary materials.; The immune system probably evolved to limit the negative effects exerted by pathogens on host homeostasis. This defence strategy relies on the concerted action of innate and adaptive components of the i...
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis
Santarino, Inês B.; Viegas, Michelle S.; Domingues, Neuza S.; Ribeiro, Ana M.; Soares, Miguel P.; Vieira, Otília V.This deposit is composed by the main article plus the supplementary materials of the publication.; Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Her...
Characterization of Plasma Labile Heme in Hemolytic Conditions
Gouveia, Zélia; Carlos, Ana Rita; Yuan, Xiaojing; Aires-da-Silva, Frederico; Stocker, Roland; J. Maghzal, Ghassan; Leal, Sónia S.; Gomes, Cláudio M.The deposited article is the accepted manuscript (post-print version) posted online 7 August 2017 and provided by The Febs Journal. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. The deposited article version cont...
Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metaboli...
Reddy, Vineel P.; Chinta, Krishna C.; Saini, Vikram; Glasgow, Joel N.; Hull, Travis D.; Traylor, Amie; Rey-Stolle, Fernanda; Soares, Miguel P.This deposit is composed by the main article plus the supplementary materials of the publication.; This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from th...
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