Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    149,755.00 €

  • Start date

    2012-04-20

  • End date

    2015-09-30

Documents

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Triple negative breast cancer: nanosolutions for a big challenge

Mendes, T.; Kluskens, Leon; Rodrigues, L. R.

Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thu...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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Selection of novel peptides homing the 4T1 CELL line: exploring alternative tar...

Silva, V.; Ferreira, Débora; Nóbrega, Franklin Luzia; Martins, Ivone M.; Kluskens, Leon; Rodrigues, L. R.

The use of bacteriophages to select novel ligands has been widely explored for cancer therapy. Their application is most warranted in cancer subtypes lacking knowledge on how to target the cancer cells in question, such as the triple negative breast cancer, eventually leading to the development of alternative nanomedicines for cancer therapeutics. Therefore, the following study aimed to select and characterize ...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Screening and characterization of novel specific peptides targeting MDA-MB-231 ...

Nóbrega, Franklin Luzia; Ferreira, Débora; Martins, Ivone M.; Maria Suarez-Diez; Azeredo, Joana; Rodrigues, L. R.; Kluskens, Leon

Background: Claudin-low breast carcinoma represents 19% of all breast cancer cases and is characterized by an aggressive progression with metastatic nature and high rates of relapse. Due to a lack of known specific molecular biomarkers for this breast cancer subtype, there are no targeted therapies available, which results in the worst prognosis of all breast cancer subtypes. Hence, the identification of novel ...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Artificial virus particles

Ferreira, Débora; Martins, Ivone M.

This chapter intends to provide an overview of the use of viruses for medical applications. The first part describes the basic characteristics of viral particles regarding their chemical composition and size, as well as their structure and assembly/disassembly abilities. Next, a discussion about the newest and most important strategies for virus particles modification including genetic, chemical, and self-assem...

Date: 2017   |   Origin: RepositóriUM - Universidade do Minho
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