Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    3599-PPCDT

  • Funding amount

    100,755.00 €

  • Start date

    2012-03-01

  • End date

    2015-08-31

Documents


In vitro design of a novel lytic bacteriophage cocktail with therapeutic potent...

Mendes, João J.; Leandro, Clara; Mottola, Carla; Barbosa, Raquel; Silva, Filipa A.; Oliveira, Manuela; Vilela, Cristina L.; Melo-Cristino, José

In patients with diabetes mellitus, foot infections pose a significant risk. These are complex infections commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, all of which are potentially susceptible to bacteriophages. Here, we characterized five bacteriophages that we had determined previously to have antimicrobial and wound-healing potential in chronic S. aureus, P. ae...


Susceptibility Patterns of Staphylococcus Aureus Biofilms in Diabetic Foot Infe...

Mottola, C; Matias, C; Mendes, JJ; Melo-Cristino, J; Tavares, L; Cavaco-Silva, P; Oliveira, M

BACKGROUND: Foot infections are a major cause of morbidity in people with diabetes and the most common cause of diabetes-related hospitalization and lower extremity amputation. Staphylococcus aureus is by far the most frequent species isolated from these infections. In particular, methicillin-resistant S. aureus (MRSA) has emerged as a major clinical and epidemiological problem in hospitals. MRSA strains have t...

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