Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    3599-PPCDT

  • Funding amount

    144,168.00 €

  • Start date

    Mon Apr 01 00:00:00 WEST 2013

  • End date

    Thu Dec 31 00:00:00 WET 2015

  • Date awarded

    Tue Mar 12 00:00:00 WET 2013

Documents


Evaluation of the ability of powdered milk to produce mini-tablets to deliver p...

Pinto, Joana T.; Brachkova, Mariya; Fernandes, Ana I.; Pinto, João F.

"This work aims to evaluate the usefulness of powdered milk as a vehicle of drugs for direct compression into mini-tablets specifically designed for the pediatric population. A 23 full factorial design was carried out to identify the effect of selected variables and their interactions (paracetamol to milk ratio, fraction of disintegrant and compression force), on selected responses (weight variation, thickness ...


Medicinal powders made of fresh milk for pediatric use

Aguiar, J. P.; Fernandes, T.; Nese, C.; Pinto, J. F.; Fernandes, A. I.

"Nowadays, the need to formulate medicines specifically designed for children is imperative [1] and solid dosage forms are the first choice for providing the required drug stability and dose accuracy. Milk, as a worldwide accepted food, is proposed in this study as a platform to deliver drugs orally in pediatrics. Therefore, the main goals of this project are: (a) to assess the properties of spray-dried milk po...


Development of casein micellar pediatric formulations

Brachkova, M. I.; Pinto, J. T.; Fernandes, A. I.; Pinto, J. F.

"The current need for medicines specifically designed for children, which consider ease of administration, dose flexibility, palatability, safety of excipients, stability and therapeutic equivalency of pediatric dosage forms, has driven the development of pediatric drug formulations. In the present work casein (CN) based micellar formulations are evaluated as vehicles for the oral delivery of pediatric drugs, s...


Effect of different excipients and processing conditions on casein micellar for...

Brachkova, Mariya; Pinto, Joana T.; Fernandes, Ana I.; Pinto, João F.

"Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."; Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutical Scientists). October 25-29, 2015, Orlando (FL), USA


Evaluation of the ability of powdered milk to produce mini-tablets containing p...

Pinto, J. T.; Brachkova, M. I.; Fernandes, A. I.; Pinto, J. F.

"In recent years the development of medicines for paediatric use have gained increase interest. Small, flexible solid dosage forms, such as mini-tablets, are an attractive choice when developing new medicines for children. Excipients, though innocuous in adults, may pose a threat to the different paediatric age groups and, therefore, milk, a complete, universally accepted food, used in children’s diet since bir...


HPLC determination of theophylline and paracetamol in fresh and powdered milk

Fernandes, T.; Aguiar, J.; Pinto, J. F.; Fernandes, A. I.

"Theophylline and paracetamol are drugs used worldwide both in human and veterinary medicine. Paracetamol (or acetaminophen) is employed as analgesic and antipyretic, and theophylline is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease. Both drugs are extensively used in pediatrics and their dosage is based on the child's body weight. Due to possible liver toxicity...


Evaluation of the ability of powdered milk to produce minitablets containing pa...

Pinto, Joana T.; Brachkova, Maryia I.; Fernandes, Ana I.; Pinto, João F.

The work aims at evaluating the usefulness of powdered milk as a drug matrix for the production of minitablets specifically designed for children. Mixtures made of powdered milk, paracetamol, mannitol, sodium croscarmellose and magnesium stearate (evaluated for flow properties, cohesiveness and caking tendency) were compacted into beams (evaluated for deformation, elasticity and stiffness) and minitablets (eval...


Simple and sensitive HPLC determination of paracetamol and theophylline in fres...

Fernandes, T. A.; Aguiar, J. P.; Fernandes, A. I.; Pinto, J. F.

Poster presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 4-7 April 2016, Glasgow, UK


Spray-dried fresh milk powders for oral drug delivery in pediatrics

Aguiar, J. P.; Fernandes, T. A.; Nese, C.; Fernandes, A. I.; Pinto, J. F.

Poster presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 4-7 April 2016, Glasgow, UK


Production and characterization of spray-dried theophylline powders prepared fr...

Aguiar, João P.; Fernandes, Tânia A. P.; Nese, Carlotta; Fernandes, Ana I.; Pinto, João F.

Objective: This work evaluates the potential of using fresh milk to deliver theophylline to children.; Methods: Theophylline–fresh milk systems were prepared using different solids ratios (0 : 1–1 : 0) and three fat contents in commercial milks (low, medium and high), which were spray-dried at different inlet air temperatures (Tinlet – 105, 130 and 150 °C). The process was evaluated for yield and the resulting ...

Report

Create a report with all publications from the project or scholarship in the current date for FCT scientific report.


Embed

Dynamically incorporate publications in your site (HTML)

								
<script type="text/javascript">
	<!--
	document.write('<div id="rcaap-widget"></div>');

	document.write('<script type="text/javascript" src="https://www.rcaap.pt/snippet?resource=documents&project=FCT%2F3599-PPCDT%2F125883&fields=id,titles,creators,issueDate,link,descriptions"></script>');
	-->
</script>