Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Gardnerella vaginalis outcompetes 29 other bacterial species isolated from BV p...

Alves, Patrícia Maria; Castro, J.; Sousa, Cármen; Cereija, Tatiana Barros Reis; Cerca, Nuno

Despite the worldwide prevalence of bacterial vaginosis (BV), its etiology is still unknown. Although BV has been associated with the presence of biofilm, the ability of BV-associated bacteria to form biofilms is still largely unknown. Here, we isolated 30 BV-associated species and characterized their virulence, using an in vitro biofilm formation model. Our data suggests that Gardnerella vaginalis had the high...


Phenotypic profiling of several strains of Pseudomonas aeruginosa : identificat...

Rodrigues, Alícia Vanessa Fontes

Dissertação de mestrado integrado em Biomedical Engineering; Numerous studies have described that bacteria display higher resistance to antimicrobials when growing in biofilm mode of growth, however the phenotypic and virulence factors changes associated with this increased resistance are still poorly understood. The goal of this study was to enlarge the knowledge about the augmented biofilmrelated resistance o...


Design of experiments to assess pre-treatment and co-digestion strategies that ...

Oliveira, J. V. M.; Alves, M. M.; Costa, J. C.

A design of experiments was applied to evaluate different strategies to enhance the methane yield of macroalgae Gracilaria vermiculophylla. Biochemical Methane Potential (BMP) of G. vermiculophylla after physical pre-treatment (washing and maceration) reached 481 ± 9 L CH4 kg−1 VS, corresponding to a methane yield of 79 ± 2%. No significant effects were achieved in the BMP after thermochemical pre-treatment, al...


Networking the way towards antimicrobial combination therapies

Jorge, Paula Alexandra Silva; Pereira, Maria Olívia; Lourenço, Anália

Publicado em "8th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2014)"; The exploration of new antimicrobial combinations is a pressing concern for Clinical Microbiology due to the growing number of resistant strains emerging in healthcare settings and in the general community. Researchers are screening agents with alternative modes of action and interest is...


On the independence of hydrogen production from methanogenic suppressor in oliv...

Gonçalves, Marta R.; Costa, J. C.; Pereira, M. A.; Abreu, A. A.; Alves, M. M.

Anaerobic degradation of olive mill wastewater (OMW) at concentrations ranging from 2 to 100 g/L of chemical oxygen demand (COD) was assessed in batch assays. Methane was the main final product obtained for the lower concentrations tested. For 25 g COD/L, H2 was temporarily produced, albeit H2 depletion occurred, likely due to homoacetogenesis, since acetate was formed concomitantly. Hydrogen was produced and a...


Modulation of crude glycerol fermentation byClostridium pasteurianum DSM 525 to...

Gallardo, R.; Alves, M. M.; Rodrigues, L. R.

High production yields and productivities are requisites for the development of an industrial butanol production process based on biodiesel-derived crude glycerol. However, impurities present in this substrate and/or the concentration of glycerol itself can affect the microbial metabolism. In this work, the effect of crude glycerol concentration on the production of butanol and 1,3-propanediol (1,3-PDO) by Clos...


Pseudomonas aeruginosa diversification during infection development in cystic f...

Sousa, A. M.; Pereira, Maria Olívia

Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung disease. Its long persistence in CF airways is associated with sophisticated mechanisms of adaptation, including biofilm formation, resistance to antibiotics, hypermutability and customized pathogenicity in which virulence factors are expressed according the infection stage. CF adaptation is triggered by high selective pressure o...


Co-digestion of Sargassum sp. with glycerol and waste frying oil following a de...

Oliveira, João Vítor; Alves, M. M.; Costa, J. C.

A response surface methodology was adopted to assess the optimal conditions for methane production from the macroalgae Sargassum sp. co-digested with glycerol (Gly) and waste frying oil (WFO). Three variables were tested: % total solids of algae (%TSSargassum sp.), co-substrate concentration (gGly/WFO L-1); and, co-substrate type (Gly or WFO). The Biochemical Methane Potential (BMP) of Sargassum sp. was 181±1 L...


Effects of biosurfactants on the viability and proliferation of human breast ca...

Duarte, Cristina; Gudiña, Eduardo J.; Lima, Cristóvão F.; Rodrigues, L. R.

Biosurfactants are molecules with surface activity produced by microorganisms that can be used in many biomedical applications. The anti-tumour potential of these molecules is being studied, although results are still scarce and few data are available regarding the mechanisms underlying such activity. In this work, the anti-tumour activity of a surfactin produced by Bacillus subtilis 573 and a glycoprotein (Bio...


Co-digestion of Sargassum sp. with glycerol and waste frying oil: optimization ...

Oliveira, João Vítor; Alves, M. M.; Costa, J. C.

A response surface methodology was adopted to assess the optimal conditions for methane production from the macroalgae Sargassum sp. Three variables were tested: % total solids of algae (%TSsargassum); co-substrate concentration (gwaste L-1); and, co-substrate type (glycerol or waste frying oil (WFO)). The Biochemical Methane Potential (BMP) of Sargassum sp. was 300 ± 3 L CH4 kg-1 COD. The co-digestion with gly...

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