Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


On the historical background of bovine colostrum

Rocha, J.

[Excerpt] Bovine colostrum, also known as “first milk” or the “first food”, is produced by healthy mammary glands until the first 72-h post-partum, after which acquires the typical physicochemical, microbiological, nutritional and rheological characteristics of milk. The colostrum is composed by unique bioactive compounds, which are divided into two main classes: immunological and growth factors. The use of col...


Selection of novel peptides homing the 4T1 CELL line: exploring alternative tar...

Silva, V.; Ferreira, Débora; Nóbrega, Franklin Luzia; Martins, Ivone M.; Kluskens, Leon; Rodrigues, L. R.

The use of bacteriophages to select novel ligands has been widely explored for cancer therapy. Their application is most warranted in cancer subtypes lacking knowledge on how to target the cancer cells in question, such as the triple negative breast cancer, eventually leading to the development of alternative nanomedicines for cancer therapeutics. Therefore, the following study aimed to select and characterize ...


Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...

Pereira, Cátia S.; Guedes, J.; Gonçalves, Marília; Loureiro, Luís; Castro, Lisandra; Gerós, Hernâni; Rodrigues, L. R.; Côrte-Real, Manuela

Breast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, significant challenges remain in the treatment of metastatic breast cancer. The recruitment of the vacuolar H+-ATPase (V-H+-ATPase) to the plasma membrane, where it mediates the acidification of the tumor microenvironment (TME), is a recognized feature involved in the acquisition of a metastatic phen...


Influence of chitosan coating on protein-based nanohydrogels properties and in ...

Bourbon, A. I.; Pinheiro, A. C.; Cerqueira, M. A.; Vicente, A. A.

Chitosan coating was applied in Lactoferrin (Lf)-Glycomacropeptide (GMP) nanohydrogels by layer-by-layer coating process. A volume ratio of 0.1 of Lf-GMP nanohydrogels (0.2 mg.mL-1, at pH 5.0) to chitosan (1 mg.mL-1, at pH 3) demonstrated to be the optimal condition to obtain stable nanohydrogels with size of 230 ± 12 nm, a PdI of 0.22 ± 0.02 and a -potential of 30.0 ± 0.15 mV. Transmission electron microscopy ...


Liquid hot water pretreatment of multi feedstocks and enzymatic hydrolysis of s...

Michelin, Michele; Teixeira, J. A.

Agricultural feedstocks (brewer spent grains BSG, corncob CC, corn husk CH, wheat straw WS and Luffa sponge LS) were pretreated by liquid hot water (LHW) in order to increase cellulose recovery and enzymatic saccharification. LHW-pretreatment resulted in hemicellulose solubilization, and solids enriched in cellulose. Chemical analysis showed different susceptibilities of the feedstocks to LHW-pretreatment and e...


Lactoferrin-based nanoparticles as a vehicle for iron in food applications: dev...

Martins, Joana; Santos, Susana Fernandes dos; Bourbon, Ana Isabel Juncá Sottomayor Lisboa; Pinheiro, Ana C.; González-Fernández, África

This study aims at developing and characterizing bovine lactoferrin (bLf) nanoparticles as an iron carrier. bLf nanoparticles were characterized in terms of size, polydispersity index (PdI), electric charge (-potential), morphology, structure and stability over time. Subsequently, iron release experiments were performed at different pH values (2.0 and 7.0) at 37 °C, in order to understand the release mechanism....


Human hair and the impact of cosmetic procedures: a review on cleansing and sha...

Cruz, Célia F.; Costa, Cristiana Filipa Chaves; Gomes, Andreia; Matamá, Teresa; Cavaco-Paulo, Artur

Hair can be strategically divided into two distinct parts: the hair follicle, deeply buried in the skin, and the visible hair fiber. The study of the hair follicle is mainly addressed by biological sciences while the hair fiber is mainly studied from a physicochemical perspective by cosmetic sciences. This paper reviews the key topics in hair follicle biology and hair fiber biochemistry, in particular the ones ...


Update on therapeutic approaches for rheumatoid arthritis

Nogueira, Eugenia; Gomes, Andreia; Preto, Ana; Cavaco-Paulo, Artur

Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that consumes considerable personal, social and economic costs. It consists of a syndrome of pain, stiffness and symmetrical inflammation of the synovial membrane (synovitis) of freely moveable joints such as the knee (diarthrodial joints). Although the etiology of rheumatoid arthritis is unclear, the disease is characterized by i...


Bio-inspired coating strategies for the immobilization of polymyxins to generat...

Alves, Diana Filipa Barros; Pereira, Maria Olívia

Microbial colonization of indwelling devices remains a major concern in modern healthcare. Developing approaches to prevent biomaterial-associated infections (BAI) is, therefore, in great demand. This study aimed to immobilize two antimicrobial peptides (polymyxins B and E) onto polydimethylsiloxane (PDMS) using two polydopamine (pDA)-based approaches: the conventional two-step method involving the deposition o...


Antimicrobial study of biosurfactants from Lactobacillus strains against skin p...

Vecino, Xanel; Rodríguez-López, L.; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.

[Excerpt] Human skin microflora is composed by resident1 temporarily resident and transient microbial species. Therefore, gram-positive bacteria from the genera Propionibacterium, Staphylococcus, Micrococcus, Corynebaderium and Acinetobacter are the majority microorganisms present in the resident microflora [1 ]. For instance, Staphylococcus epidermidis is the main constituent of skin microflora, which protects...

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