Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tub...

Silva, João P.; Gonçalves, Carine; Costa, C.; Sousa, Jeremy; Silva-Gomes, Rita; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. M.

uberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient compliance due to the expensive, long-lasting and multi-drug standard therapies often results in treatment failure and emergence of multi-drug resistant strains. In this scope, antimicrobial peptides (AMPs) arise as promising candidates for T...


Essential oil-water emulsions containing a biosurfactant from Lactobacillus par...

Vecino, Xanel; Ferreira, A.; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.

[Excerpt] Surfactants play important roles in cosmetic products due to diverse properties including as emulsifier, foaming, wetting, detergency and solubilizer agents, among others. However, the market for beauty and personal care products based on natural ingredients has shown a relevant growth. In this sense, biosurfactants being non-toxic, biodegradable and ecofriendly natural compounds are suitable replacer...


Bioactive properties and functional constituents of Hypericum androsaemum L.: A...

Jabeur, Inés; Tobaldini-Valerio, Flávia; Martins, Natália; Barros, Lillian; Martins, I.; Calhelha, Ricardo C.; Henriques, Mariana; Silva, Sónia Carina

Hypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. A marked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lines was also observed, whereas no toxicity was shown against non-tumor porcine liver cells (> 400 ?g/mL). The extract was also effective in inhibiting nitric oxide production, as an indicator of th...


Characterization of an in vitro fed-batch model to obtain cells released from S...

França, Ângela; Carvalhais, Virgínia Maria Dinis; Vilanova, Manuel; Pier, Gerald B.; Cerca, Nuno

Both dynamic and fed-batch systems have been used for the study of biofilms. Dynamic systems, whose hallmark is the presence of continuous flow, have been considered the most appropriate for the study of the last stage of the biofilm lifecycle: biofilm disassembly. However, fed-batch is still the most used system in the biofilm research field. Hence, we have used a fed-batch system to collect cells released fro...


Discrimination of clinically relevant Candida species by Fourier-transform infr...

Silva, Sónia Carina; Tobaldini-Valerio, Flávia; Costa-de-Oliveira, Sofia; Henriques, Mariana; Azeredo, Joana; Ferreira, Eugénio C.; Lopes, João Almeida

Accurate Candida species identification remains a challenge due to their phenotypic and genotypic similarity. Species belonging to the *psilosis group, are even described as phenotypically indistinguishable. Also, most of the genotypic methods commonly used to discriminate these species are laborious and very expensive. In this work we developed a Fourier-transform infrared spectroscopy with attenuated total re...


Tackling Nitrosomonas europaea culture problems for future applications in insh...

Padrão, Jorge; Susana Cortez; Dias, Nicolina; Nicolau, Ana; Mota, M.

Worldwide aquaculture production represents nearly 160 million tonnes per year, roughly the double of captured fish. Technological improvements are required to provide and improve sustainability to the constant aquaculture production growth. Inshore aquaculture reduces dramatically the risk of infection of the cultured organisms, as sea water is treated before use. Contrariwise, to prevent the increase of opera...


Insights into interspecies interactions, phenotypic profile and antimicrobial s...

Grainha, Tânia Raquel Rodrigues

Ventilator associated pneumonia (VAP) is the second most common nosocomial infection in the intensive care units (ICU) and the most common in mechanically ventilated patients. VAP presents a serious problem in ICU due to high mortality and morbidity rates associated, because it is often biofilm-mediated and polymicrobial. Therefore, understanding the impact of microorganisms in VAP and their interaction is a ma...


Folate-targeted nanoparticles for rheumatoid arthritis therapy

Nogueira, Eugénia Sofia Costa; Gomes, Andreia C.; Preto, Ana; Cavaco-Paulo, Artur

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease, affecting almost 1% of the world population. Although the cause of RA remains unknown, the complex interaction between immune mediators (cytokines and effector cells) is responsible for the joint damage that begins at the synovial membrane. Activated macrophages are critical in the pathogenesis of RA and have been shown to specifically...


Effect of chitosan-Aloe vera coating on postharvest quality of blueberry (Vacci...

Vieira, Jorge M.; Flores-López, M. L.; Jasso de Rodríguez, D.; Sousa, Maria C.; Vicente, A. A.; Martins, Joana

The present study was carried out to evaluate the effect of chitosan-based edible coatings with Aloe vera extract on the postharvest blueberry fruit quality during storage at 5 °C. Firstly, A. vera fractions (pulp and liquid) were extracted from leaves and evaluated in terms of antifungal and antioxidant capacities. The choice of the most adequate chitosan and A. vera fraction concentrations to be incorporated ...


Compositional features and bioactive properties of whole fraction from Aloe ver...

López, M.; Romaní, Aloia; Cerqueira, M. A.; Rodríguez-García, Raúl; Rodríguez, Diana Jasso de; Vicente, A. A.

Aloe vera processing leaves generates a liquid and bagasse fraction. The resulting bagasse is mostly discarded as waste. Both the bagasse and liquid fraction can have interesting metabolites with biological activities for pharmaceutical and agro-food industries. The main objectives of the present work were: (1) to characterize the gel, liquid fraction and bagasse of A. vera; (2) to obtain extracts from bagasse ...

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