Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country


  • Funding program


  • Funding amount

    338,852.00 €

  • Start date


  • End date



Developing a model for cystic fibrosis sociomicrobiology based on antibiotic an...

Lopes, Susana P.; Azevedo, Nuno Filipe; Pereira, Maria Olívia

Cystic fibrosis (CF) infections are invariably biofilm-mediated and polymicrobial, being safe to assume that a myriad of factors affects the sociomicrobiology within the CF infection site and modulate the CF community dynamics, by shaping their social activities, overall functions, virulence, ultimately affecting disease outcome. This work aimed to assess changes in the dynamics (particularly on the microbial c...

Synthesis of fusion genes for cloning by megaprimer-based PCR

Aguiar, Tatiana Quinta; Oliveira, Carla Cristina Marques de; Domingues, Lucília

The polymerase chain reaction (PCR) is the technique of choice used to obtain DNA for cloning, because it rapidly provides high amounts of desired DNA fragments and allows the easy introduction of extremities adequate for enzyme restriction or homologous recombination, and of artificial, native, or modified sequence elements for specific applications. In this context, the use of megaprimer-based PCR strategies ...

Perspectives in anaerobic digestion of lipid-rich wastewater

Holohan, B. C.; Duarte, Maria Salomé; Corbacho, M. A. Szabo; Cavaleiro, Ana Júlia; Salvador, Andreia Filipa Ferreira; Frijters, C.; Pacheco-Ruiz, S.

Lipid-rich wastewaters are ideal sources for methane production, but lipids are generally separated and removed prior to anaerobic treatment to avoid sludge flotation and microbial inhibition. In this work, we review the major technological and microbiological advances in the anaerobic digestion (AD) of lipids, while highlighting the most important breakthroughs in the field and identifying the future perspecti...

Neutral PEGylated liposomal formulation for efficient folate-mediated delivery ...

Nogueira, E.; Freitas, Jaime; Loureiro, Ana Isabel Sá; Nogueira, Patrícia; Gomes, Andreia C.; Preto, Ana; Carmo, Alexandre M.; Moreira, Alexandra

Cationic liposomes are efficient vectors for systemic delivery of therapeutic small interfering RNA (siRNA), taking advantage of RNA interference (RNAi), a naturally occurring gene-silencing mechanism in mammalian cells. However, toxicity at high concentrations, short circulating half-lives and lack of specificity restrict their successful application in a wider scale. The purpose of this study was to evaluate ...

Evaluation of Saccharomyces cerevisiae as an anti-fumonisin B-1 additive in a h...

Taran, F. M. P.; Silva, V. P.; Abrunhosa, Luís; Rosa, C. A. R.; Venâncio, Armando; Almeida, F. Q.

In this study, the capacity of Saccharomyces cerevisiae to adsorb fumonisin B-1 (FB1) was evaluated in in vitro assays. The digestion of nutrients from maize contaminated with FB1 was assessed as well as the influence of digestive enzymes and pH on the bioavailability of FB1 in solution. Adsorption assays in buffers containing 5 mu g/ml of FB1 were conducted to determine the strain to be used in the in vitro di...

17 - Cyanobacterial toxins as a high value-added product

Geada, Pedro; Gkelis, S.; Teixeira, J. A.; Vasconcelos, V.; Vicente, A. A.; Fernandes, Bruno D.

Cyanotoxins are known to cause severe damage to humans and animals. However, these metabolites are also considered as very promising compounds with potential use in biomedical treatments (e.g., anticancer/antitumor drug development) and to act against bacteria, fungi, algae, and insects. Despite the increasing demand of such high value-added products both for research and industrial applications, their availabi...

Filamentous fungal human pathogens from food emphasising Aspergillus, Fusarium ...

Paterson, R. R. M.; Lima, Nelson

Disease caused by filamentous fungal human pathogens (FFHP) is increasing. These organisms cause severe mycoses in immunosuppressed individuals, such as those: (a) with AIDS; (b) having undergone transplantation; and/or (c) undergoing chemotherapy. Immunocompetent people can become infected. Some FFHP are isolated from foods which may be fomites. However, the information concerning particular species on specifi...

A design of experiments to assess methane production from anaerobic co-digestio...

Oliveira, João Vítor; Duarte, T.; Costa, J. C.; Cavaleiro, Ana Júlia; Pereira, M. A.; Alves, M. M.

Redirection of sewage sludge in wastewater treatment plants (WWTP) from landfilling or incineration to biological treatment, for instance anaerobic digestion, has become a part of the current global environmental, economic and regulatory issues. A statistical approach, based on a design of experiments, was adopted in order to assess methane production from the anaerobic co-digestion of mixed sewage sludge (MS) ...

Evaluation of process conditions in the bigels production: a multivariate analysis

Fasolin, Luiz H.; Vicente, A. A.

Bigels are complex biphasic gels, composed by the mixture of organogel and hydrogel. These systems have been exploited mainly due to their ability to act as vehicle for hydrophilic and lipophilic simultaneously, being very attractive for food, pharmaceutical and cosmetic applications. However, despite the increasing number of publications concerning the production and use of bigels in recent years, to our knowl...

In vitro evaluation of an antibiofilm product: a combination between bacterioph...

Silva, Ana Catarina Ramos Lopes da

Chronic skin wounds represent a major burn both economically and socially. Pseudomonas aeruginosa and Escherichia coli are among the most common colonizers of infected wounds and are prolific biofilm formers. Biofilms are a major problem in infections due to their increasingly difficult control and eradication, and tolerance to multiple prescribed drugs. As so, alternative methods are necessary. Bacteriophages ...


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