Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


The prevalence of Gardnerella vaginalis in Portuguese pregnant women and the se...

Machado, Daniela Marlene da Silva

A nível mundial, a bacteriose vaginal (BV) é a infeção vaginal mais comum em mulheres em idade reprodutiva, associando-se a complicações na gravidez. Esta infeção carateriza-se pela diminuição da população microbiana vaginal normal (predominantemente lactobacilar) e a simultânea proliferação de bacterias anaeróbias. Devido à sua natureza polimicrobiana, a etiologia da BV permanece por esclarecer. No entanto, o ...


Carbon nanotubes accelerate methane production in pure cultures of methanogens ...

Salvador, Andreia F.; Martins, Gilberto; Melle-Franco, Manuel; Serpa, Ricardo; Stams, Alfons Johannes Maria; Cavaleiro, Ana Júlia; Pereira, M. Alcina

Carbon materials have been reported to facilitate direct interspecies electron transfer (DIET) between bacteria and methanogens improving methane production in anaerobic processes. In this work, the effect of increasing concentrations of carbon nanotubes (CNT) on the activity of pure cultures of methanogens and on typical fatty acid-degrading syntrophic methanogenic coculture was evaluated. CNT affected methane...


HC-0C-03: Biological treatments to improve the quality of heavy crude oils

Gudiña, Eduardo J.; Teixeira, J. A.

Petroleum or crude oil is a crucial source of energy and one of the main factors driving the Worlds economy. The progressive depletion of high-quality crudes in the last decades will make necessary the exploitation of unconventional low-quality heavy and extra-heavy crudes to meet future energy demands. However, their exploitation requires the application of special techniques in order to facilitate their recov...


Substrate inhibition of uracil phosphoribosyltransferase (UPRT) in distinct mic...

Aguiar, Tatiana Quinta; Silva, Rui; Oliveira, Carla; Domingues, Lucília

Background: Unlike the established practice, the supply of exogenous uracil cannot fully rescue uracil auxotrophy in Ura- mutants of some species of industrial and/or medical significance (e.g. Ashbya gossypii, Candida guilliermondii, C. albicans, Leishmania donovani), which require uridine for proper growth [1-4]. Here we reveal the molecular mechanism underlying this phenotype in A. gossypii and disclose comm...


Physicochemical study of biomolecular interactions between lysosomotropic surfa...

Janek, Tomasz; Czyznikowska, Zaneta; Luczynski, Jacek; Gudiña, Eduardo J.; Rodrigues, L. R.; Galezowska, Joanna

The interactions between two cationic lysosomotropic surfactants (2-dodecanoyloxyethyl)trimethylammonium bromide (DMM-11) and (2-dodecanoyloxypropyl)trimethylammonium bromide (DMPM-11) with bovine serum albumin (BSA) in Hepes buffer (pH = 7.4) were systematically studied by surface tension, fluorescence and circular dichroism (CD) spectroscopy and isothermal titration calorimetry (ITC). Furthermore, the size of...


Hydroxycinnamic acids and curcumin production in engineered Escherichia coli us...

Rodrigues, Joana L.; Couto, Márcia; Araújo, R.; Kristala L. J. Prather; Kluskens, Leon; Rodrigues, L. R.

Hydroxycinnamic acids and curcumin are compounds with great therapeutic potential, including anticancer properties. In this study, p-coumaric acid, caffeic acid and curcumin were produced in Escherichia coli. Their production was induced by heat using the dnaK and ibpA heat shock promoters. The ribosome binding site (RBS) used was tested and further optimized for each gene to assure an efficient translation. p-...


Micro- and nano bio-based delivery systems for food applications: In vitro beha...

Simões, Lívia de Souza; Madalena, Daniel A.; Pinheiro, Ana Cristina; Teixeira, J. A.; Vicente, A. A.; Ramos, Óscar L.

Micro- and nanoencapsulation is an emerging technology in the food field that potentially allows the improvement of food quality and human health. Bio-based delivery systems of bioactive compounds have a wide variety of morphologies that influence their stability and functional performance. The incorporation of bioactive compounds in food products using micro- and nano-delivery systems may offer extra health be...


The yeast-like fungus Aureobasidium thailandense LB01 produces a new biosurfact...

Meneses, D.; Gudiña, Eduardo J.; Fernandes, Fabiano; Gonçalves, Luciana R. B.; Rodrigues, L. R.; Rodrigues, Sueli

In this study, the biosurfactant production by an Aureobasidium thailandense LB01 was reported for the first time. Different agro-industrial by-products (corn steep liquor, sugarcane molasses, and olive oil mill wastewater) were evaluated as alternative low-cost substrates. The composition of the culture medium was optimized through response surface methodology. The highest biosurfactant production (139 ± 16 mg...


Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for d...

Dias, Nicolina; Dias, M. C.; Cavaleiro, C.; Sousa, M. C.; Lima, Nelson; Machado, M.

Essential oils (EOs) extracted from Lavandula luisieri and Cymbopogon citratus were tested for their antifungal activity against ten clinical isolates of dermatophytes isolated from cases of tinea pedis. Inhibition of conidial germination and antifungal drug/EO combination assay were tested on two ATCC reference strains of Trichophyton rubrum and Trichophyton mentagrophytes. EOs were characterised by high amoun...


Sodium lauryl ether sulfate (SLES) degradation by nitrate-reducing bacteria

Paulo, Ana M. S.; Aydin, Rozelin; Dimitrov, Mauricio R.; Vreeling, Harm; Cavaleiro, Ana Júlia; García-Encina, Pedro A.; Stams, Alfons Johannes Maria

The surfactant sodium lauryl ether sulfate (SLES) is widely used in the composition of detergents and frequently ends up in wastewater treatment plants (WWTPs). While aerobic SLES degradation is well studied, little is known about the fate of this compound in anoxic environments, such as denitrification tanks of WWTPs, nor about the bacteria involved in the anoxic biodegradation. Here, we used SLES as sole carb...

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