Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Flow cytometry as a tool for assessing spore cell viability

Calado, Thalita; Feio, M.; França, Ângela Maria Oliveira Sousa; Abrunhosa, Luís; Venâncio, Armando

ICFC 2017 - International Conference on Food Contaminants (Book of Abstracts)


Ashbya gossypii riboflavin overproducing strains are highly susceptible to ligh...

Silva, Rui; Aguiar, Tatiana Quinta; Oliveira, Rui; Domingues, Lucília

Background The overproduction of riboflavin by Ashbya gossypii, which is one of the most distinctive traits of this filamentous hemiascomycete, is triggered by oxidative stress [1]. In turn, riboflavin is a strong photosensitizer that upon irradiation with light has been shown to generate reactive oxygen species (ROS) and induce oxidative DNA damage in mammalian cells [2-3]. Envisioning a better understanding o...


Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. plank...

Castro, Joana Isabel Reis; França, Angela; Bradwell, Katie R.; Serrano, Myrna G.; Jefferson, K. K.; Cerca, Nuno

Bacterial vaginosis is the most common gynecological disorder affecting women of reproductive age. Bacterial vaginosis is frequently associated with the development of a Gardnerella vaginalis biofilm. Recent data indicates that G. vaginalis biofilms are more tolerant to antibiotics and are able to incorporate other bacterial vaginosis -associated species, yielding a multi-species biofilm. However, despite its a...


Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights thro...

Pérez-Pérez, Martín; Jorge, Paula; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália

Quorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databas...


A multi-metal risk assessment strategy for natural freshwater ecosystems based ...

Alves, Cristina M.; Ferreira, Carlos M. H.; Soares, Eduardo V.; Soares, Helena M. V. M.

Scientifically sound risk assessment strategies and derivations of environmental quality standards for metals present in freshwater environments are currently hampered by insufficient chronic toxicity data collected from natural ecosystems, as well as inadequate information on metal speciation. Thus, the aim of the present study was to evaluate the impact of freshwater containing multiple metals (Cd, Cr, Cu, Ni...


Gamma irradiation in ochratoxin A control

Calado, Thalita; Verde, Sandra Cabo; Venâncio, Armando; Abrunhosa, Luís

Ochratoxin A (OTA) is one of the main mycotoxins found in food. Gamma radiation is used for preserving foods since it inactivates pathogens. The effect of irradiation on mycotoxins has been studied but results are contradictory. The different matrices and conditions used by several authors may have influenced reported results. The aim of this work was to study the effects of gamma radiation in OTA in order to e...


A network perspective on antimicrobial peptide combination therapies: the poten...

Jorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália

Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial and anti-resistance research. The objective of this study was to review the available scientific literature on the effects of antimicrobial combinations involving colistin (polymyxin E), polymyxin B and nisin, which are US Food and Drug Administration (FDA)-approved AMPs broadly tested ...


Sodium chloride effect on the aggregation behaviour of rhamnolipids and their a...

Rodrigues, Ana Isabel; Gudiña, Eduardo J.; Teixeira, J. A.; Rodrigues, L. R.

In this work, the antifungal activity of rhamnolipids produced by Pseudomonas aeruginosa #112 was evaluated against Aspergillus niger MUM 92.13 and Aspergillus carbonarius MUM 05.18. It was demonstrated that the di-rhamnolipid congeners were responsible for the antifungal activity exhibited by the crude rhamnolipid mixture, whereas mono-rhamnolipids showed a weak inhibitory activity. Furthermore, in the presenc...


Bacteriophages and their derivatives for the treatment and control of food-prod...

Carvalho, Carla M.; Costa, Ana Rita; Silva, F.; Oliveira, A.

Nowadays, the world is facing an increasing emergence of antibiotic resistant bacteria. Simultaneously, the banning of some existing antibiotics and the lack of development of new antimicrobials have created an urgent need to find new alternatives against animal infections. Bacteriophages (phages) are naturally occurring predators of bacteria, ubiquitous in the environment, with high host specificity and harmle...


Biosurfactants in cosmetic formulations: trends and challenges

Vecino, Xanel; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.

Cosmetic products play an essential role in everyones life. People everyday use a large variety of cosmetic products such as soap, shampoo, toothpaste, deodorant, skin care, perfume, make-up, among others. The cosmetic industry encompasses several environmental, social and economic impacts that are being addressed through the search for more efficient manufacturing techniques, the reduction of waste and emissio...

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