Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Photonic modulation of EGFR: 280nm low level light arrests cancer cell activati...

Botelho, C. M.; Marques, Rogério Filipe Fernandes; Viruthachalam, Thiagarajan; Gonçalves, Odete Sofia Lopes; Vorum, Henrik; Gomes, Andreia C.

Overexpression of the Epidermal Growth Factor Receptor (EGFR) by cancer cells is associated with a poor prognosis for the patient. For several decades, therapies targeting EGFR have been designed, including the use of monoclonal antibodies and small molecule tyrosine kinase inhibitors. The use of these molecules had good clinical results, although its efficiency (and specificity) is still far from being optimal...


Formation, stability and antioxidant activity of food-grade multilayer emulsion...

Acevedo-Fani, Alejandra; Silva, Hélder D.; Soliva-Fortuny, Robert; Martín-Belloso, Olga; Vicente, A. A.

Interfacial deposition of biopolymer layers on oil droplets may be a suitable strategy for increasing the emulsion stability and protection of functional ingredients. Resveratrol is a naturally occurring phenolic compound with numerous health-promoting properties, but its usage is still restricted due to its poor water solubility and high chemical instability. The aim of this study was to formulate single-layer...


Oral mucositis caused by Candida glabrata biofilms: failure of the concomitant ...

Rodrigues, Célia F.; Henriques, Mariana

Objectives: Candida glabrata is becoming one of the most prevalent pathogenic yeasts in cases of oral diseases. Mucositis is an recurrent oral infection in immunocompromised patients, and the actual guidelines recommend the use of fluconazole (Flu) for many cases. However, the azole resistance by C. glabrata is renowned, causing a reduced therapeutic response, especially when it occurs in biofilms. In this stud...


Staphylococcus epidermidis is largely dependent on iron availability to form bi...

Oliveira, Fernando E.; França, Angela; Cerca, Nuno

Staphylococcus epidermidis has long been known as a major bacterial coloniser of the human skin, yet it is also a prominent nosocomial pathogen. Its remarkable ability to assemble structured biofilms has been its major known pathogenic feature to date. Notwithstanding important discoveries that have been accomplished, several questions about S. epidermidis biofilm formation still remain to be elucidated. This s...


Immobilization of bioactive compounds in Cassia grandis galactomannan-based fil...

Albuquerque, Priscilla B. S.; Cerqueira, Miguel A.; Vicente, António A.; Teixeira, J. A.; Carneiro-da-Cunha, Maria G.

Galactomannan extracted from Cassia grandis seeds was used for the production of films containing different concentrations of the bioactive compounds lactoferrin (LF), bioactive peptides (BAPs), and phytosterols. SEM, FTIR, mechanical and thermal properties, colour, moisture content (MC), solubility, water vapour permeability (WVP), and contact angle (CA) were performed evaluating the effect of increasing conce...


Interspecies interactions and bacteriophage control in S. Enteritidis and E. co...

Milho, Catarina; Silva, Maria Daniela; Alves, Diana; Azeredo, Joana; Sillankorva, Sanna

Background Salmonella Enteritidis and Escherichia coli are both important foodborne pathogens, commonly related to outbreaks1. Their ability to form biofilms contributes to their virulence and enables their survival on different food contact surfaces2. In mixed biofilms, interspecies interactions can occur, resulting in positive, negative or neutral outcomes to each species3,4. As these microbial communities pr...


Utilização de grânulos de cortiça para estimular a biorremediação aeróbia de hi...

Freitas, Carlos Jorge Batista

Os derrames de petróleo constituem um dos desastres ambientais mais graves provocados pelo Homem. Uma das estratégias mais utilizadas para remediação de locais contaminados com petróleo é a contenção e remoção dos hidrocarbonetos por materiais sorventes. Entre estes, a cortiça tem sido aplicada com sucesso na remediação de derrames de óleos. Pelas suas características físico-químicas, a cortiça pode constituir ...


Investigating bacterial community changes and organic substrate degradation in ...

Barbosa, Sónia G.; Peixoto, L.; ter Heijne, Annemiek; Kuntke, P.; Alves, M. M.; Pereira, M. Alcina

The present study investigates the changes in the microbial community and the degradation of organic compounds in a microbial fuel cell (MFC) operated on human urine. An anaerobic community was enriched in urine-degrading electroactive microorganisms by stepwise lowering the dilution factor of the anode media from 50 times diluted to undiluted urine. In a duplicated assay a current density of 495±16 mA m-2, a c...


Discriminating between typical and atypical cystic fibrosis-related bacterial s...

Lopes, Susana P.; Carvalho, Daniel T.; Pereira, Maria Olívia; Azevedo, Nuno F.

This study aims to report the development of peptide nucleic acid (PNA) probes to specifically detect the cystic fibrosis (CF)-associated traditional and atypical species Pseudomonas aeruginosa and Inquilinus limosus, respectively. PNA probes were designed in silico, developed and tested in smears prepared in phosphate-buffer saline and in artificial sputum medium. A multiplex fluorescent in situ hybridization ...


Adsorption of aflatoxin B1, zearalenone and ochratoxin A by microorganisms isol...

Taheur, Fadia Ben; Fedhila, Kais; Chaieb, Kamel; Kouidhi, Bochra; Bakhrouf, Amina; Abrunhosa, Luís

A strategy to reduce the deleterious effects of mycotoxins is to use dietary supplements that contain microorganisms that bind mycotoxins and diminish their gastrointestinal absorption. Novel strains were isolated from a Kefir culture and assessed for their mycotoxin adsorption and biotransformation ability. The most active strains were identified using DNA sequencing, and the stability of microorganism/mycotox...

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