Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Magnetic carbon nanotubes as a new generation of electron shuttles for anaerobi...

Antunes, Ana Catarina Gomes

Pharmaceuticals and their metabolites are considered emerging pollutants due to their continuous input into the aquatic environment, representing a public health problem. The conventional treatment systems are not effective in the removal of these type of compounds, which are usually concentrated in the sludge line that is often stabilized by anaerobic digestion. However, the anaerobic reduction rate is slow du...


Changing the shape of hair with keratin peptides

Cruz, Célia F.; Sá, M.; Antunes, Egipto; Osorio, H.; Ribeiro, Artur; Cavaco-Paulo, Artur

Chemical straightening of curly human hair fibres involves the use of strong reducing agents at alkaline pH. Human hair is made of keratin, and the fixation of fibre shape involves the reduction and reformation of new disulphide bonds between keratin molecules. Here, we propose an alternative and green methodology using keratin peptide sequences (10-13 residues) derived from the human genome. In a previous stud...


Vineyard pruning waste as an alternative carbon source to produce novel biosurf...

Vecino, Xanel; Rodríguez-López, L.; Gudiña, Eduardo J.; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.

Abstract Cellulosic sugars extracted from vineyard pruning waste (VPW) were used as a low-cost carbon source for biosurfactant production by Lactobacillus paracasei. The results obtained showed that when glucose from VPW was used, the biosurfactant was a glycolipopeptide, whereas when it was replaced by lactose the biosurfactant produced was a glycoprotein. Additionally, it was found that the extraction process...


Synergistic antimicrobial interaction of honey and bacteriophage in Escherichia...

Ribeiro, Henrique; Oliveira, Ana Cristina Afonso; Silva, Ana Catarina Ramos Lopes; Silva, Maria Daniela; Rodrigues, Célia Fortuna

Wound colonization by biofilms-forming bacteria is one of the main obstacles to the treatment of chronic wounds, causing a number of biological and financial problems. Biofilms are structured communities of bacterial cells enclosed in a self-produced polymeric matrix, adhered to inert or living surfaces, blocking antibiotics and patients immune cells from reaching bacteria. Bacterio(phages), viruses infecting e...


Targetability of hyaluronic acid nanogel to cancer cells: In vitro and in vivo ...

Pedrosa, Sílvia S.; Pereira, Paula; Correia, A.; Gama, F. M.

We have, in previous work developed, characterized and evaluated the biocompatibility of an engineered hyaluronic acid nanogel. Here we assess the targetability of a hyaluronic acid nanogel towards CD44 overexpressing cells, in vitro and in vivo. Results obtained by flow cytometry and confocal fluorescence microscopy shows that nanogel is greatly internalized by non-small cancer lung cells (A549 cells), that ov...


Effect of a peptide in cosmetic formulations for hair volume control

Cruz, Célia F.; Ribeiro, Artur J.; Sá, M.; Cavaco-Paulo, Artur

Objective The capacity of hair to absorb water causes changes in its physical and cosmetic properties under different environmental conditions. Hence, the control of hair volume in variable relative humidity settings is an important topic in cosmetics. The behaviour of two types of hair, Caucasian and Asian, was studied regarding their volume change in different relative humidity conditions. The ability of a pe...


Influence of nutritional and operational parameters on the production of butano...

Marusich, R.; Alves, M. M.; Rodrigues, L. R.

Butanol and 1,3-propanediol (1,3-PDO) are simultaneously produced by Clostridium pasteurianum from glycerol. In this study, random chemical mutagenesis of C. pasteurianum DSM 525 was conducted to improve its tolerance to butanol. Selected nutritional and operational parameters were evaluated to identify strategies that favour the production of each metabolite. From those experiments, it was possible to isolate ...


Creating functional nanostructures: Encapsulation of caffeine into α-lactalbumi...

Fuciños, C.; Míguez, Martín; Fuciños, Pablo; Pastrana, Lorenzo M.; Rúa, María L.; Vicente, A. A.

This work evaluated the stability and functionality of nanotubes obtained from α-lactalbumin (α-LA). α-LA nanotubes' structure was highly stable during a freeze-drying process but not after grinding. The ability of α-LA nanotubes to encapsulate caffeine, used as a model molecule, was evaluated. α-La nanotubes were highly effective for this purpose as encapsulation efficiency (%EE) was near 100% and loading capa...


Peptideprotein interactions within human hair keratins

Cruz, Célia F.; Azoia, Nuno G.; Matamá, Teresa; Cavaco-Paulo, Artur

We selected 1235 decapeptides from human hair proteins encoded by human genes of keratins and keratin associated proteins. The peptides were linked to glass arrays and screened for their affinity towards a solution of human hair extracted keratin fraction. Based on the physicochemical properties of the peptides, ten variables were studied: content of different types of amino acid side chains (cysteine, hydropho...


Bioelectrochemically-assisted recovery of valuable resources from urine: invest...

Barbosa, Sónia Glória Linhares

Source separated urine is highly concentrated in nutrients and biodegradable compounds. This thesis explores the potential of combining nutrient recovery from urine with simultaneous energy production in bioelectrochemical systems (BESs). Non-spontaneous phosphorus (P) recovery by struvite precipitation was analysed by adding three different magnesium (Mg) sources (magnesium chloride (MgCl2), magnesium hydroxid...

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