Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Hair coloration by gene regulation: fact or fiction?

Matamá, Maria Teresa; Gomes, Andreia C.; Cavaco-Paulo, Artur

The unravelling of hair pigmentation genetics and robust delivery systems to the hair follicle (HF) will allow the development of a new class of colouring products. The challenge will be changing hair colour from inside out by safely regulating the activity of target genes through the specific delivery of synthetic/natural compounds, proteins, genes, or small RNAs.


Triple negative breast cancer: nanosolutions for a big challenge

Mendes, T.; Kluskens, Leon; Rodrigues, L. R.

Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thu...


Improved burn wound healing by the antimicrobial peptide LLKKK18 released from ...

Silva, João P.; Dhall, S.; Garcia, M; Costa, C.; Chan, A.; Gama, F. M.; Martins-Green, M.

Antimicrobial peptides (AMPs) are good candidates to treat burn wounds, a major cause of morbidity, impaired life quality and resources consumption in developed countries. We took advantage of a commercially available hydrogel, Carbopol, a vehicle for topical administration that maintains a moist environment within the wound site. We hypothesized that the incorporation of LLKKK18 conjugated to dextrin would imp...


Integrating data from heterogeneous DNA microarray platforms

Valente, Eduardo; Rocha, Miguel

DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data dimensionality p...


Enabling systematic, harmonised and large-scale biofilms data computation: the ...

Pérez-Rodríguez, Gael; Glez-Peña, Daniel; Azevedo, N. F.; Pereira, Maria Olívia; Fdez-Riverola, Florentino; Lourenço, Anália

Background and Objective: Biofilms are receiving increasing attention from the biomedical community. Biofilm-like growth within human body is considered one of the key microbial strategies to augment resistance and persistence during infectious processes. The Biofilms Experiment Workbench is a novel software workbench for the operation and analysis of Biofilms experimental data. The goal is to promote the inter...


Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluore...

Machado, António; Castro, J.; Cereija, Tatiana Barros Reis; Almeida, Carina; Cerca, Nuno

Bacterial vaginosis (BV) is one of most common vaginal infections. However, its diagnosis by classical methods reveals low specificity. Our goal was to evaluate the accuracy diagnosis of 150 vaginal samples with research gold standard methods and our Peptide Nucleic Acid (PNA) probes by Fluorescence in situHybridization (FISH) methodology. Also, we described the first PNA-FISH methodology for BV diagnosis, whic...


Assessing synergistic interaction between Gardnerella vaginalis and other uroge...

Castro, Joana; Machado, Daniela Marlene da Silva; Cerca, Nuno


Marky: a tool supporting annotation consistency in multi-user and iterative doc...

Pérez-Pérez, Martín; Glez-Peña, Daniel; Fdez-Riverola, Florentino; Lourenço, Anália

Background and Objectives Document annotation is a key task in the development of Text Mining methods and applications. High quality annotated corpora are invaluable, but their preparation requires a considerable amount of resources and time. Although the existing annotation tools offer good user interaction interfaces to domain experts, project management and quality control abilities are still limited. Theref...


Ashbya gossypii beyond industrial riboflavin production: a historical perspecti...

Aguiar, Tatiana Quinta; Silva, R.; Domingues, Lucília

The filamentous fungus Ashbya gossypii has been safely and successfully used for more than two decades in the commercial production of riboflavin (vitamin B2). Its industrial relevance combined with its high genetic similarity with Saccharomyces cerevisiae together promoted the accumulation of fundamental knowledge that has been efficiently converted into a significant molecular and in silico toolbox for its ge...


Development and characterization of an active chitosan-based film containing qu...

Souza, M.; Vaz, Antônio F. M.; Silva, H.; Cerqueira, M. A.; Vicente, A. A.; Carneiro-da-Cunha, Maria G.

This work aims at developing an active chitosan film through the incorporation of quercetin and the evaluation of physical and functional properties of the films made thereof. The addition of quercetin showed to influence films properties in terms of surface morphology, tensile strength, and opacity while elongation-at-break, thickness, water vapor, and oxygen permeability were not significantly affected with i...

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