Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Anti-biofilm peptide combinations in the eradication of pre-established biofilm...

Jorge, Paula Alexandra Silva; Grzywacz, Diana; Kamysz, Wojciech; Lourenço, Anália; Pereira, Maria Olívia

The emergence of resistance is a preoccupant health threat and the development of new strategies and the use of novel compounds are in demand. Specifically, biofilm infections are a serious threat, causing chronic, nosocomial and biomaterial related infections, being related to dissemination of antibiotic resistance. Pseudomonas aeruginosa and Staphylococcus aureus are great developers of resistance and their a...


Optimization of biogas production from Sargassum sp. using a design of experime...

Oliveira, J. V. M.; Alves, M. M.; Costa, J. C.

A Design of Experiments was adopted to assess the optimal conditions for methane production from the macroalgae Sargassum sp. co-digested with glycerol (Gly) and waste frying oil (WFO). Three variables were tested:% total solids of algae (%TSSargassumsp.), co-substrate concentration (gGly/WFO L-1); and, co-substrate type (Gly or WFO). The Biochemical Methane Potential (BMP) of Sargassum sp. was 181±1 L CH4 kg-1...


BV and non-BV associated Gardnerella vaginalis establish similar synergistic in...

Castro, J.; Cerca, Nuno

Dual-species biofilm formation between Gardnerella vaginalis strains isolated from women with or without bacterial vaginosis (BV) and other 24 BV-associated microorganisms support that the key difference in virulence potential between BV-negative and BV-positive G. vaginalis strains seems not to be related with biofilm maturation.


The first Paenibacillus larvae bacteriophage endolysin (PlyPl23) with high pote...

Oliveira, A.; Leite, Marta; Kluskens, Leon; Santos, Sílvio Roberto Branco; Melo, Luís D. R.; Azeredo, Joana

Endolysins, which are peptidoglycan-degrading enzymes expressed during the terminal stage of the reproduction cycle of bacteriophages, have great potential to control Gram-pos- itive pathogens. This work describes the characterization of a novel endolysin (PlyPl23) encoded on the genome of Paenibacillus larvae phage phiIBB_Pl23 with high potential to control American foulbrood. This bacterial disease, caused by...


Optimization of in vitro model for growth of Gardnerella vaginalis biofilm

Machado, Daniela Marlene da Silva; Oliveira, A. Palmeira de; Cerca, Nuno

Bacterial vaginosis (BV) is the most common vaginal disorder in women of reproductive age. Despite its high prevalence, BV aetiology remains elusive. Recently, it was described that BV occurrence involves the presence of an adherent biofilm on vaginal epithelium, being Gardnerella vaginalis the predominant bacterial species. Furthermore, this bacterial biofilm persists on the vaginal epithelium after therapy wi...


Polydopamine-mediated immobilization of PALM and DNAse to create an anti-adhesi...

Alves, Diana Filipa Barros; Jorge, Paula Alexandra Silva; Pereira, Maria Olívia

The development of novel approaches to prevent biomaterial-associated infections are in great demand in modern healthcare. A mussel-inspired coating strategy was applied to introduce both anti-adhesive and antimicrobial functionalities on silicone material. Substrates were immersed in an alkaline solution of dopamine to form a thin layer of polydopamine and then transferred into a solution containing different ...


Data quality in biofilm high-throughput routine analysis: intralaboratory proto...

Jorge, Paula Alexandra Silva; Lourenço, Anália; Pereira, Maria Olívia

Biofilm research is growing more diverse and dependent on high-throughput technologies and the large-scale production of results aggravates data substantiation. In particular, it is often the case that experimental protocols are adapted to meet the needs of a particular laboratory and no statistical validation of the modified method is provided. This paper discusses the impact of intra-laboratory adaptation and...


Fluconazole versus Voriconazole: Candida glabrata biofilms response to differen...

Rodrigues, Célia Fortuna; Gonçalves, Bruna; Rodrigues, E.; Silva, Sónia Carina; Azeredo, Joana; Henriques, Mariana

Candida glabrata is the second most prevalent yeast in fungal infections, especially in immunocompromised and/or hospitalized patients. The azole resistance within this species is very well-known and results in a low therapeutic response of C. glabrata infections, particularly when associated with biofilms. Objective - To understand the different efficacies of two azoles against C. glabrata biofilms: - fluconaz...


Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infect...

Pires, Diana; Boas, Diana Patrícia Andrade Vilas; Sillankorva, Sanna; Azeredo, Joana

Antimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics and nowadays, a common infection can be fatal. To revert this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since P. aeruginosa is one of the most common causes of ...


Relationship between galactomannan structure and physicochemical properties of ...

Santos, V.; Souza, B.; Teixeira, J. A.; Vicente, A. A.; Cerqueira, M. A.

In this work five sources of galactomannans, Adenanthera pavonina, Cyamopsis tetragonolobus, Caesalpinia pulcherrima, Ceratonia siliqua and Sophora japonica, presenting mannose/galactose ratios of 1.3, 1.7, 2.9, 3.4 and 5.6, respectively, were used to produce galactomannan-based films. These films were characterized in terms of: water vapour, oxygen and carbon dioxide permeabilities (WVP, O 2 P and CO 2 P); moi...

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