Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country


  • Funding program


  • Funding amount

    338,852.00 €

  • Start date


  • End date



Mutagens affect food and water biodeteriorating fungi

Paterson, R. R. M.; Lima, Nelson

Many areas of food mycology could be affected detrimentally by mutation of wild type fungi. Some of these will contact mutagens from pre-isolation to experimentation and the effect on fungi isolated from mycotoxin-contaminated food is assessed for the first time in this review. However, this mutagen issue is not considered by other authors in primary research papers, which is relevant to molecular biology techn...

Perspectives on the biotechnological production and potential applications of l...

Silvério, Sara C.; Macedo, Eugénia A.; Teixeira, J. A.; Rodrigues, L. R.

Lactosucrose is a synthetic trisaccharide composed of galactose, glucose and fructose. This compound is obtained through enzymatic synthesis using lactose and sucrose as substrates. The enzymes involved in the process are able to catalyse both hydrolysis and transfer reactions. The yield and productivity of the process are usually affected by the occurrence of parallel hydrolysis of the newly formed product (la...

In vitro evaluation of bovine lactoferrin potential as an anticancer agent

Zhang, Yunlei; Lima, Cristóvão F.; Rodrigues, L. R.

Bovine lactoferrin (bLF) was shown to efficiently inhibit the growth of MCF-7, T-47D, MDA-MB-231 and Hs578T breast cancer cells in a concentration-dependent manner. However, apoptosis was only induced in MCF-7 cells, which was associated with the mitochondria membrane depolarisation and a decrease of Bcl-2 levels. bLF led to the cycle arrest of MCF-7 cells at G1/G0 phase, as well as a significant decrease in th...

Plants used in folk medicine: the potential of their hydromethanolic extracts a...

Martins, Natália; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina

Currently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, wer...

Antimicrobial and anti-adhesive activities of cell-bound biosurfactant from Lac...

Gudiña, Eduardo J.; Fernandes, Elisabete Ramos; Teixeira, J. A.; Rodrigues, L. R.

In this work, biosurfactant production by different Lactobacillus strains was studied using the conventional MRS medium for lactic acid bacteria. Lactobacillus agilis CCUG31450 produced a cell-bound biosurfactant that reduced the surface tension of water to 42.5 mN/m, and exhibited a high emulsifying activity (E24=60%). The amount of biosurfactant produced was 84 mg/l, with a cmc of 7.5 mg/ml. A preliminary che...

Determination of the importance of iron acquisition for Staphylococcus epidermi...

Soares, Pedro Miguel Oliveira

Nosocomial infections are a worldwide concern due to their impact on patients’ health and costs to the health care system. The majority of these infections are associated with the use of indwelling medical devices, which serve as scaffold for biofilm formation by bacteria or other microorganisms. Due to its remarkable capability to form biofilms on medical devices, Staphylococcus epidermidis, a commensal bacter...

Heterologous production of curcuminoids

Rodrigues, Joana Lúcia Lima Correia; Prather, Kristala L. J.; Kluskens, Leon; Rodrigues, L. R.

Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attractive targets for heterologo...

How do Candida glabrata´s biofilms respond to antifungal drugs?

Rodrigues, Célia Fortuna; Rodrigues, E.; Silva, Sónia Carina; Azeredo, Joana; Henriques, Mariana

Candida species are responsible for recurrent human infections, mostly in immunocompromised patients, due to their high vulnerability. Candida glabrata has been shown to have a major role in these infections being the second most prevalent species involved in human fungemia. Objective: To understand the effect of three different antifungal agents Fluconazole (Flu), Amphotericin B (AmB) and Caspofungin (Csf) - i...

Optimization of culture conditions for Gardnerella vaginalis biofilms formation

Machado, D.; Palmeira-de-Oliveira, Ana; Cerca, Nuno

Bacterial vaginosis is the leading vaginal disorder in women in reproductive age. Although bacterial vaginosis is related with presence of a biofilm composed predominantly by Gardnerella vaginalis, there has not been detailed information addressing the environmental conditions influence in the biofilm formation of this bacterial species. Here, we evaluated the influence of some common culture conditions on G. v...

New approach on the bioconversion of vineyard pruning waste into surface-active...

Vecino, X.; Rodríguez-López, L.; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.


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