Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Hydrocarbonoclastic bacteria: from bioremediation to bioenergy feedstock

Carvalho, Ana Rita Castro

Bacterial storage lipids are being considered as viable alternative feedstocks for industrial and biotechnological applications, compared to conventional ones. The production of these bacterial compounds can be obtained from different carbon sources, including inexpensive and recalcitrant wastes. This thesis explores the potential of using hydrocarbonoclastic bacteria to obtain lipid reserve substances from hyd...


Activity of phenolic compounds from plant origin against Candida species

Martins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia Carina; Ferreira, Isabel C. F. R.

Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular ta...


Transformation of Escherichia coli JM109 using pUC19 by the Yoshida effect

Mendes, Gabriel; Vieira, Pedro S.; Lanceros-Méndez, S.; Kluskens, Leon; Mota, M.

Transformation of non-competent Escherichia coli JM109 was accomplished using pUC19 as donor plasmid and sepiolite as the acicular material to promote cell piercing via application of friction with a polystyrene stick or a magnetic bar on the surface of a hydrogel containing agar. An automatic spreading setup was built with a conventional stirring plate and compared to manual spreading. Several parameters were ...


Biosurfactant production by Bacillus subtilis using corn steep liquor as cultur...

Gudiña, Eduardo J.; Fernandes, Elisabete Clara Resende; Rodrigues, A. I.; Teixeira, J. A.; Rodrigues, L. R.

In this work, biosurfactant production by Bacillus subtilis #573 was evaluated using corn steep liquor (CSL) as culture medium. The best results were obtained in a culture medium consisting of 10% (v/v) of CSL, with a biosurfactant production of about 1.3 g/l. To the best of our knowledge, this is the first report describing biosurfactant production by B. subtilis using CSL as culture medium. Subsequently, the ...


Influence of glucose concentration on the structure and quantity of biofilms fo...

Pereira, Leonel; Silva, Sónia Carina; Ribeiro, Bruno; Henriques, Mariana; Azeredo, Joana

Candida parapsilosis is nowadays an emerging opportunistic pathogen and its increasing incidence is part related to the capacity to produce biofilm. In addition, one of the most important C. parapsilosis pathogenic risk factors includes the organisms\textquoteright selective growth capabilities in hyper alimentation solutions. Thus, in this study, we investigated the role of glucose in C. parapsilosis biofilm m...


Evidence for inter- and intra-species biofilm formation variability among a sma...

Oliveira, Fernando E.; Lima, C.; Brás, S.; França, Ângela; Cerca, Nuno

Coagulase-negative staphylococci (CoNS) are common bacterial colonisers of the human skin. They are often involved in nosocomial infections due to biofilm formation in indwelling medical devices. While biofilm formation has been extensively studied in Staphylococcus epidermidis, little is known regarding other CoNS species. Here, biofilms from six different CoNS species were characterised in terms of biofilm co...


Evaluation of bioactive properties and phenolic compounds in different extracts...

Martins, Natália; Barros, Lillian; Santos-Buelga, Celestino; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R.

The therapeutic benefits of medicinal plants are well known. Nevertheless, essential oils have been the main focus of antioxidant and antimicrobial studies, remaining scarce the reports with hydrophilic extracts. Thus, the antioxidant and antifungal activities of aqueous (prepared by infusion and decoction) and methanol/water (80:20, v/v) extracts of sage (Salvia officinalis L.) were evaluated and characterized...

Date: 2015   |   Origin: Biblioteca Digital do IPB

Plants used in folk medicine: the potential of their hydromethanolic extracts a...

Martins, Natália; Ferreira, Isabel C.F.R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia

Currently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, wer...

Date: 2015   |   Origin: Biblioteca Digital do IPB

Activity of phenolic compounds from plant origin against Candida species

Martins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R.

Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular ta...

Date: 2015   |   Origin: Biblioteca Digital do IPB

In vivo anti-Candida activity of phenolic extracts and compounds: future perspe...

Martins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R.

Candida species have increasingly deserved a special attention among the medical community. In spite of the presence of Candida species as a human commensal, alarming rates of local and systemic infections have been observed, varying from moderate to severe impact. Currently available antifungal drugs have progressively lost their effectiveness, pointing urgently the problem of the microorganisms with acquired-...

Date: 2015   |   Origin: Biblioteca Digital do IPB

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