Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Biocompatibility of a self-assembled crosslinkable hyaluronic acid nanogel

Pedrosa, Sílvia Santos; Pereira, Paula Alexandra Cunha; Correia, Alexandra; Moreira, Susana; Rocha, Huho; Gama, F. M.

Hyaluronic acid nanogel (HyA-AT) is a redox sensitive crosslinkable nanogel, obtained through the conjugation of a thiolated hydrophobic molecule to the hyaluronic acid chain. Engineered nanogel was studied for its biocompatibility, including immunocompatibility and hemocompatability. The nanogel did not compromise the metabolic activity or cellular membrane integrity of 3T3, microvascular endothelial cells, an...


Reconstruction of the network of experimentally validated AMP-drug combinations...

Jorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Fdez-Riverola, Florentino; Pereira, Maria Olívia; Lourenço, Anália

The combination of antimicrobial products is a promising biomedical strategy against the ever growing number of resistant strains emerging in healthcare and community settings. Agents with alternative modes of action, such as antimicrobial peptides (AMPs), and the efficacy of combined actions are being evaluated. Despite the availability of various antimicrobial data repositories, a wealth of information remain...


Phage display technology in biomaterials engineering: progress and opportunitie...

Martins, Ivone M.; Reis, R. L.; Azevedo, Helena S.

The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo approaches that leverage on the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous sys...


Acetylated bacterial cellulose coated with urinary bladder matrix as a substrat...

Gonçalves, S.; Rodrigues, I. P.; Padrão, Jorge; Silva, João P.; Sencadas, Vítor João Gomes Silva; Lanceros-Méndez, S.; Girão, H.; Gama, F. M.

This work evaluated the effect of acetylated bacterial cellulose (ABC) substrates coated with urinary bladder matrix (UBM) on the behavior of Retinal Pigment Epithelium (RPE), as assessed by cell adhesion, proliferation and development of cell polarity exhibiting transepithelial resistance and polygonal shaped-cells with microvilli. Acetylation of bacterial cellulose (BC) generated a moderate hydrophobic surfac...


Screening and characterization of novel specific peptides targeting MDA-MB-231 ...

Nóbrega, Franklin Luzia; Ferreira, Débora; Martins, Ivone M.; Maria Suarez-Diez; Azeredo, Joana; Rodrigues, L. R.; Kluskens, Leon

Background: Claudin-low breast carcinoma represents 19% of all breast cancer cases and is characterized by an aggressive progression with metastatic nature and high rates of relapse. Due to a lack of known specific molecular biomarkers for this breast cancer subtype, there are no targeted therapies available, which results in the worst prognosis of all breast cancer subtypes. Hence, the identification of novel ...


A biologically active delivery material with dried-rehydrated vesicles containi...

Ferreira, Helena; Silva, Raquel; Matamá, Maria Teresa; Silva, Carla; Gomes, Andreia C.; Cavaco-Paulo, Artur

AbstractChronic wounds usually remain in the inflammatory phase of the healing process during several months or even years. Hence, a continuous research has been resulting in the development of wound dressings with improved performance. Herein, we report a delivery system for cutaneous wound healing, consisting of a textile material (non-woven gauzes) covered with lipidic vesicles containing diclofenac, a non-s...


Plasma is the main regulator of Staphylococcus epidermidis biofilms virulence g...

França, Ângela Maria Oliveira Sousa; Cerca, Nuno

Staphylococcus epidermidis is frequently associated with the emergence of medical device- associated bloodstream infections, due to its ability to form biofilms on the surface of vascular catheters. Although these biofilms may be in continuous contact with human blood, how S. epidermidis biofilm cells interact with blood and its cellular and soluble components is poorly understood. Herein, we evaluated biofilm ...


Quantitative image analysis as a tool for Yarrowia lipolytica dimorphic growth ...

Braga, Adelaide; Mesquita, D. P.; Amaral, A. L.; Ferreira, Eugénio C.; Belo, Isabel

Yarrowia lipolytica, a yeast strain with a huge biotechnological potential, capable to produce metabolites such as γ-decalactone, citric acid, intracellular lipids and enzymes, possesses the ability to change its morphology in response to environmental conditions. In the present study, a quantitative image analysis (QIA) procedure was developed for the identification and quantification of Y. lipolytica W29 and ...


Inflammatory response to dextrin-based hydrogel associated with human mesenchym...

Silva, D.; Caseiro, Ana Rita; Amorim, Irina; Pereira, Isabel; Faria, Fátima; Pereira, Tiago; Santos, José Domingos; Gama, F. M.; Maurício, Ana Colette

Increasing relevance has been attributed to hydrogels due to their ability to provide an extracellular matrix (ECM)-like environment for cellular adhesion and proliferation, acting as mechanical scaffolds for tissue remodeling or as delivery matrices. In vivo biocompatibility of a hybrid dextrin hydrogel produced from oxidized dextrin and adipic acid dihydrazide and its combinations with human mesenchymal stem ...


Effect of voriconazole on Candida tropicalis biofilms: Relation with ERG genes ...

Fernandes, T.; Silva, Sónia Carina; Henriques, Mariana

Candida tropicalis has emerged as the third most prevalent fungal pathogens and its ability to form biofilms has been considered one of the most important virulence factors, since biofilms represent high tolerance to antifungal agents. However, the mechanisms of C. tropicalis biofilm resistance to antifungals remain poorly understood. Thus, the main aim of this work was to infer about the effect of voriconazole...

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