Project/scholarship details


  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    338,852.00 €

  • Start date

    2013-01-01

  • End date

    2015-12-31

Documents


Biocatalytic approaches using lactulose: end product compared with substrate

Silvério, Sara C.; Macedo, Eugénia A.; Teixeira, J. A.; Rodrigues, L. R.

Lactulose is a lactose-based carbohydrate with well-known prebiotic effect and recognized medical applications. Currently, the commercially available lactulose is chemically synthesized. Nevertheless, the process leads to low yields and high levels of by-products. Alternatively, lactulose can be produced by enzymatic synthesis, which provides a cleaner production under mild conditions. Two different enzymatic r...


Olive pomace valorization by Aspergillus species: lipase production using solid...

Oliveira, Felisbela Maria Araújo; Moreira, C.; Salgado, José Manuel; Abrunhosa, Luís; Venâncio, Armando; Belo, Isabel

Background Pollution by olive mill wastes is an important problem in the Mediterranean area and novel solutions for their proper management and valorization are needed. The aim of this work was to optimize a solid-state fermentation (SSF) process to produce lipase using olive pomace (OP) as the main source of nutrients by several Aspergillus spp. Optimized variables in two different designs were: ratio between ...


In silico constraint-based strain optimization methods: the quest for optimal c...

Silva, P.; Rocha, Miguel; Rocha, I.

Shifting from chemical to biotechnological processes is one of the cornerstones of 21st century industry. The production of a great range of chemicals via biotechnological means is a key challenge on the way toward a bio-based economy. However, this shift is occurring at a pace slower than initially expected. The development of efficient cell factories that allow for competitive production yields is of paramoun...


Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors

Gonçalves, B.; Ferreira, C.; Alves, Carlos; Henriques, Mariana; Azeredo, Joana; Silva, Sónia Carina

Vulvovaginal candidiasis (VVC) is an infection caused by Candida species that affects millions of women every year. Although Candida albicans is the main cause of VVC, the identification of non-Candida albicans Candida (NCAC) species, especially Candida glabrata, as the cause of this infection, appears to be increasing. The development of VVC is usually attributed to the disturbance of the balance between Candi...


Lipase production by Aspergillus ibericus using oil cakes and its application i...

Oliveira, Felisbela Maria Araújo; Sousa, C. E.; Ribeiro, B. D.; Peclat, V. R. O. L.; Coelho, M. A. Z.; Venâncio, Armando; Belo, Isabel

Agro-industrial residues are a good nutrient source which may be applied in biotechnological processes. The aim of this work was to optimize lipase production using Aspergillus ibericus MUM 03.49 in different oil cakes (OC) produced in Brazil, by solid-state fermentation (SSF) process; and to apply produced lipase in esterification reactions for aroma esters production. SSFs were performed in 250 mL Erlenmeyer´...


Propolis: a potential natural product to fight Candida species infections

Tobaldini-Valerio, Flávia; Bonfim-Mendonça, P. S.; Rosseto, H. C.; Bruschi, M. L.; Henriques, Mariana; Negri, Melyssa; Silva, Sónia Carina

Aim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficien...


Ultrasounds pretreatment of olive pomace to improve xylanase and cellulase prod...

Leite, A.; Salgado, José Manuel; Venâncio, Armando; Domínguez, José Manuel; Belo, Isabel

Abstract Olive mills generate a large amount of waste that can be revaluated. This work aim to improve the production lignocellulolytic enzymes by solid-state fermentation using ultrasounds pretreated olive mill wastes. The composition of olive mill wastes (crude and exhausted olive pomace) was compared and several physicochemical characteristics were significantly different. The use of both wastes in SSF was e...


Development of a novel aptamer-based multi-sensor device for the detection of o...

Meirinho, Sofia G.

Breast cancer is the most prevalent cancer in women worldwide and its mortality is closely associated with the development of metastasis of the primary tumor. It is currently the fifth cause of death from cancer (522,000 deaths), with 1.67 million new breast cancer cases estimated in 2012. An early diagnosis is crucial to improve patients survival and disease prognostic. Hence, sensitive and specific methods ou...


Response surface design to study the influence of inoculum, particle size and i...

Costa, J. C.; Oliveira, J. V.; Alves, M. M.

Ulex europaeus is one of the world worst invaders vegetal species and its suitability for biogas production is significant. The effect of three factors affecting the Biochemical Methane Potential (BMP, expressed as volume of CH4 per mass of volatile solids of waste) and the biodegradability rate (k, expressed in volume of CH4 per mass of VS and time) of U. europaeus was assessed by a Central Composite Face Cent...


Construction of antimicrobial peptide-drug combination networks from scientific...

Jorge, P.; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Fdez-Riverola, Florentino; Pereira, Maria Olívia; Lourenço, Anália

Considerable research efforts are being invested in the development of novel antimicrobial therapies effective against the growing number of multi-drug resistant (MDR) pathogens. Notably, the combination of different agents is increasingly explored as means to exploit and improve individual agent actions while minimising microorganism resistance. Although there are several databases on antimicrobial agents, sci...

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