Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    3599-PPCDT

  • Funding amount

    498,869.00 €

  • Start date

    2013-06-01

  • End date

    2016-12-31

Documents

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The effect of albumin and cholesterol on the biotribological behavior of hydrog...

Silva, D.; Fernandes, A. C.; Nunes, T. G.; Colaço, R.; Serro, A. P.

The irritation/discomfort associated with the use of contact lenses (CLs) is often related to the eyelid-lens friction. Although the use of such devices is widespread, the information about the influence of the lacrimal fluid biomolecules on the tribological behavior of the CLs hydrogels is scarce. In this work, we investigated the effect of the presence of albumin and cholesterol in the lubricant medium, on th...

Date: 2015   |   Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
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Controlled drug release from hydrogels for contact lenses: drug partitioning an...

Pimenta, A.F.R.; Ascenso, J.; Fernandes, J.C.S.; Colaço, R.; Serro, A.P.; Saramago, B.

Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorh...

Date: 2016   |   Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
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Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compou...

Lenis‐Rojas, Oscar A.; Roma‐Rodrigues, Catarina; Fernandes, Alexandra R.; Carvalho, Andreia; Cordeiro, Sandra; Guerra‐Varela, Jorge; Sánchez, Laura

Project ED431C 2018/39 PEst 20152020 UID/QUI/00100/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020; The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non‐platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are ...

Date: 2021   |   Origin: Repositório Institucional da UNL
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