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An Overview of Monkeypox Virus Detection in Different Clinical Samples and Anal...

Cordeiro, Rita; Pelerito, Ana; de Carvalho, Isabel Lopes; Lopo, Sílvia; Neves, Raquel; Rocha, Raquel; Palminha, Paula; Verdasca, Nuno

Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases. The positivity rate was higher for lesion (91.3%) and rectal sw...


Fifteen years of a nationwide culture collection of Neisseria gonorrhoeae antim...

Pinto, Miguel; Rodrigues, João Carlos; Matias, Rui; Água-Doce, Ivone; Cordeiro, Dora; Correia, Cristina; Gomes, João Paulo; Borrego, Maria José

Neisseria gonorrhoeae antimicrobial resistance (AMR) and gonorrhea disease burden remain major public health concerns worldwide. To contribute to the supranational demands to monitor and manage the spread of antimicrobial-resistant N. gonorrhoeae, the Portuguese NIH promoted the creation of the National Laboratory Network for Neisseria gonorrhoeae Collection (PTGonoNet). The present study reports the N. gonorrh...


Hepatitis C in a Mobile Low-Threshold Methadone Program

Silva, Mário J; Pereira, Cláudia; Loureiro, Rafaela; Balsa, Catarina; Lopes, Paulo; Água-Doce, Ivone; Belo, Elsa; Martins, Helena C; Coutinho, Rodrigo

Introduction: Data on the epidemiology of hepatitis C among individuals who use drugs in low-threshold settings are lacking, although crucial to assess the burden of disease and aid in the design of treatment strategies. Objective: The aim of this study was to characterize the epidemiology and disease related to hepatitis C in a population attending a low-threshold methadone program. Materials and methods: A cr...


Evolução de casos de transmissão VIH da mãe ao filho em Portugal

Pádua, Elizabeth; Almeida, Catarina; Água-Doce, Ivone; Nunes, Baltazar; Martins, Helena Cortes


Hepatite E: diagnóstico serológico em hepatites de etiologia desconhecida

Manita Ferreira, Carla; Almeida Santos, João; Água-Doce, Ivone; Lourenço, Teresa; Benoliel, Camalavati; Matos, Rita; Cortes Martins, Helena

Introdução A infeção por VHE tem maior incidência nos países em desenvolvimento, nomeadamente no sudoeste asiático, como por exemplo a Índia e a China, surgindo nos restantes países como casos importados. Recentemente foram descritos casos de hepatite E em países desenvolvidos sem que estivesse presente o principal fator de risco, viagens recentes a zonas endémicas, sugerindo a existência de reservatórios do VH...


Evolução de casos de transmissão VIH-1 da mãe ao filho em Portugal

Pádua, Elizabeth; Almeida, Catarina; Água-Doce, Ivone; Cortes Martins, Helena

Introdução: Um dos maiores sucessos no combate à infeção VIH/SIDA foi a redução das taxas de transmissão mãe-filho (TMF) em resultado da implementação de estratégias preventivas. Objetivo: Análise da evolução das taxas de TMF do VIH-1 entre 1999-2010 em crianças nascidas de mães infetadas seguidas através de um protocolo laboratorial para diagnóstico precoce da TMF implementado pelo Laboratório Nacional de Refe...


CMV and HCV infections in HIV/non-HIV mothers and newborns: prevalence, frequen...

Lopo, Sílvia; Pereira, Maria Amável; Mendonça, Joana; Vinagre, Elsa; Reis, Tânia; Cordeiro, Dora; Almeida, Catarina; Água-Doce, Ivone; Manita, Carla

The incidence of HIV infections in gestational age is an important Public Health issue as are concerns about co-infection with opportunistic viruses, such as CMV/HCV. Several authors refer higher ratios of congenital CMV infection in children born to HIV infected mother than in uninfected. In the case of HCV, perinatal transmission increases in cases of mothers co-infected with HIV. Aims:To study CMV/HCV infect...


Molecular Epidemiology of Hepatitis A Virus in a Group of Portuguese Citizens L...

Rodrigues, Luisa; Pista, Angela; Oliveira, Ana; Água-Doce, Ivone; Manita, Carla; Paixão, Teresa

Hepatitis A virus (HAV) is the most important cause of acute infectious hepatitis worldwide. In Portugal, due to improvements in sanitation epidemic outbreaks of HAV infection have become less frequent. This report is the first, to our knowledge that characterized HAV in Portugal. For the detection and molecular characterization of HAV cases in a group of Portuguese individuals in the Lisbon area, 31 serum samp...


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