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High-intensity infrasound effects on glucose metabolism in rats
Pereira, Gonçalo Martins; Santos, Madalena; Pereira, Sofia S.; Borrecho, Gonçalo; Tortosa, Francisco; Brito, José; Freitas, DiamantinoRecent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar...
Effects of high-intensity infrasound on liver lipid content of rats
Pereira, Gonçalo Martins; Pereira, Sofia S.; Santos, Madalena; Brito, José; Freitas, Diamantino; Carvalho, António Oliveira de; Águas, ArturPrevious experimental studies show that exposure to noise with high and audible frequencies causes multiple metabolic alterations, such as increased liver glycogen and triglycerides. However, the effect of exposure to sound with lower frequencies, such as high-intensity infrasound (frequency <20 Hz and sound pressure level >90 dB), on the liver lipid content is still unclear. As such, we aimed to study the effe...
Periodontal status, perceived stress, diabetes mellitus and oral hygiene care o...
Machado, Vanessa; Botelho, João; Proença, Luís; Alves, Ricardo; Oliveira, Maria João; Amaro, Luís; Águas, Artur; Mendes, José JoãoBackground: To determine if periodontal risk assessment (PRA), the number of missing teeth, diabetes mellitus (DM), perceived stress and interproximal cleaning are associated with oral health-related quality of life (OHRQoL), using Andersen’s behavioral modelling (ABM). Material and methods: Data derived from 472 adults derived from a representative population of the Study of Periodontal Health in Almada-Seixal...
Perceived xerostomia, stress and periodontal status impact on elderly oral heal...
Botelho, João; Machado, Vanessa; Proença, Luís; Oliveira, Maria João; Cavacas, Maria Alzira; Amaro, Luís; Águas, Artur; Mendes, José JoãoBackground: To investigate if self-perceived xerostomia and stress are significant variables on the Oral-Health Related Quality of Life (OHRQoL) of elderly patients, considering the periodontal status, oral hygiene habits and sociodemographic characteristics simultaneously. Methods: The study cohort included 592 participants (320 females/272 Males), aged 65 years or older, representing the elder inhabitants of ...
HEPATIC CELL PROLIFERATION PEAKS ONE WEEK AFTER PORTAL VEIN LIGATION AND IS NOT...
Guimarães, Marta; Morais, Tiago; Pereira, Sofia S.; Monteiro, Ana; Vilaça, Ana; Ferreira, Tiago; Castro, Tiago; Rodrigues, Pedro; Oliveira, VeraIntroduction: Selective portal vein ligation is currently used to induce hypertrophy of healthy liver segments before partial hepatectomy performed to treat metastatic or primary liver cancer. A major limitation of this procedure is the time interval needed between the portal ligation and hepatic resection, potentially leading to tumour progression. We report the characterization of the liver regeneration kinet...
Low-frequency noise effects on the rat parotid gland: a transmission electron m...
Oliveira, Pedro; Pereira, Gonçalo Martins; Simões, Margarida Seara; Monteiro, Emanuel; Matos, António Pedro Alves de; Águas, ArturIntroduction: Low-frequency noise (LFN) is a ubiquitous physical stressor known to cause degenerative cellular changes and organ alterations with functional repercussions both in humans and animals. Materials and methods: After acceptance of the study protocol by a local ethics committee, 20 Wistar rats were randomly divided into two equal groups. One group was kept in silence and the other continuously exposed...
Spontaneous one-lung ventilation increases the lung inflammatory response : an ...
Machado, Humberto S.; Sá, Paula; Nunes, Catarina S.; Couceiro, António; Silva, Álvaro Moreira da; Águas, ArturStudy objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure. Design: In vivo prospective randomised animal study Setting: University research laboratory Subjects: New Ze...
Increased lung inflammation with oxygen supplementation in tracheotomized spont...
Machado, Humberto S.; Nunes, Catarina S.; Sá, Paula; Couceiro, António; Silva, Álvaro Moreira da; Águas, ArturBackground Mechanical ventilation is a well–known trigger for lung inflammation. Research focuses on tidal volume reduction to prevent ventilator-induced lung injury. Mechanical ventilation is usually applied with higher than physiological oxygen fractions. The purpose of this study was to investigate the after effect of oxygen supplementation during a spontaneous ventilation set up, in order to avoid the infla...
Effects of large pressure amplitude low frequency noise in the parotid gland pe...
Oliveira, Pedro; Brito, José; Mendes, José João; Fonseca, Jorge da; Águas, Artur; Martins dos Santos, José"Introduction: In tissues and organs exposed to large pressure amplitude low frequency noise fibrosis occurs in the absence of inflammatory signs, which is thought to be a protective response. In the parotid gland the perivasculo-ductal connective tissue surrounds arteries, veins and the ductal tree. Perivasculo-ductal connective tissue is believed to function as a mechanical stabilizer of the glandular tissue....
Immunohistochemical evaluation of cardiac connexin43 in rats exposed to low-fre...
Antunes, Eduardo; Borrecho, Gonçalo; Oliveira, Pedro; Brito, José; Águas, Artur; Martins dos Santos, José"Introduction: Low-frequency noise (LFN) leads to an abnormal proliferation of collagen and development of tissue fibrosis. It has been shown that myocardial fibrosis in association with gap junction remodeling occurs in several cardiac diseases and can be implicated in the development of ventricular tachyarrhythmias. We previously reported a strong development of myocardial fibrosis induced by LFN in rats but ...