2 documents found, page 1 of 1
The Impact of IPTi and IPTc Interventions on Malaria Clinical Burden – In Silic...
Águas, R.; Lourenço, J.M.L.; Gomes, M.G.M.; White, L.J.BACKGROUND: Clinical management of malaria is a major health issue in sub-Saharan Africa. New strategies based on intermittent preventive treatment (IPT) can tackle disease burden by simultaneously reducing frequency of infections and life-threatening illness in infants (IPTi) and children (IPTc), while allowing for immunity to build up. However, concerns as to whether immunity develops efficiently in treated i...
Pertussis: increasing disease as a consequence of reducing transmission
Gomes, Maria Gabriela Miranda; Águas, R.; Gonçalves, G.Since the 1980s, the occurrence of pertussis cases in developed countries has increased and shifted towards older age groups. This resurgence follows 30 years of intense mass vaccination, and has been attributed primarily to three factors: (1) more effective diagnosis of the disease, (2) waning of vaccine-induced immunity, and (3) loss of vaccine efficacy due to the emergence of new Bordetella pertussis strains...