3 documents found, page 1 of 1
Bowman-Birk protease inhibitor from Vigna unguiculata seeds enhances the action...
Álvares, Alice da Cunha Morales; Schwartz, Elisabeth Nogueira Ferroni; Amaral, Nathalia Oda; Trindade, Neidiane Rosa; Pedrino, Gustavo RodriguesThe hydrolysis of bradykinin (Bk) by different classes of proteases in plasma and tissues leads to a decrease in its half-life. Here, Bk actions on smooth muscle and in vivo cardiovascular assays in association with a protease inhibitor, Black eyed-pea trypsin and chymotrypsin inhibitor (BTCI) and also under the effect of trypsin and chymotrypsin were evaluated. Two synthetic Bk-related peptides, Bk1 and Bk2, w...
Activity of scorpion venom-derived antifungal peptides against planktonic cells...
Guilhelmelli, Fernanda; Vilela, Nathália; Smidt, Karina S.; Oliveira, Marco Antônio de; Álvares, Alice da Cunha MoralesThe incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and acquired resistance of some fungal species to available therapies, associated with the high toxicity of these drugs on the present scenario and makes an imperative of the search for new, more efficient and less toxic therapeutic choices. Antimicrobial pep...
Efeito do inibidor de serinoproteases black-eyed pea trypsin and chymotrypsin i...
Álvares, Alice da Cunha MoralesTese (doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Biofísica, 2014.; A bradicinina (Bk) é um nonapeptídeo vasodilatador que apresenta regiões com aminoácidos susceptíveis à ação de proteases. Quando metabolizada, a Bk não promove vasodilatação, devido à meia-vida reduzida. O objetivo deste trabalho é analisar a atividade da Bk e de dois ...