Encontrados 15 documentos, a visualizar página 1 de 2
Immune Profile After Oral Immunotherapy in Children With Persistent Cow’s Milk ...
Ângelo-Dias, Miguel; Martins, Catarina; Piedade, Susana; Gaspar, Ângela; Mota, Inês; Borrego, Luís MiguelPurpose: Cow’s milk protein allergy (CMPA) is the most common food allergy in childhood. Oral immunotherapy (OIT) has proven effective in achieving tolerance in children with persistent CMPA (pCMPA), although the underlying immunological mechanisms that allow for tolerance remain incompletely understood. We aimed to characterize the immune profile of pCMPA children following successful OIT and compare it to hea...
Immune Profile After Oral Immunotherapy in Children With Persistent Cow's Milk ...
Ângelo-Dias, Miguel; Martins, Catarina; Piedade, Susana; Gaspar, Ângela; Mota, Inês; Borrego, Luís-MiguelPURPOSE: Cow's milk protein allergy (CMPA) is the most common food allergy in childhood. Oral immunotherapy (OIT) has proven effective in achieving tolerance in children with persistent CMPA (pCMPA), although the underlying immunological mechanisms that allow for tolerance remain incompletely understood. We aimed to characterize the immune profile of pCMPA children following successful OIT and compare it to hea...
Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss
Lima, Jorge; Guerreiro, João; Ângelo-Dias, Miguel; Silvério Serra, Sofia; Costa, Teresa; Marto, Natália; de Pinho, João Feldman; Costa, JoãoFunding Information: The author(s) declare that financial support was received for the research and/or publication of this article. This study in the context of the \u201CWomen\u2019s Health and Maternal Fetal Research Group\u201D was partially co-financed by Hospital da Luz Lisboa under the initiative \u201CLuz Investiga\u00E7\u00E3o.\u201D The sponsor did not have any role in the study design, in the collecti...
PD-1 Expression in Endometriosis
Reis, José Lourenço; Martins, Catarina; Ângelo-Dias, Miguel; Rosa, Natacha Nurdine; Borrego, Luís Miguel; Lima, JorgeBackground: Endometriosis, believed by many to be rooted in immunology, is a chronic disease. Upregulation of programmed cell death protein 1 (PD-1) in immune cells may compromise their defensive function, a mechanism demonstrated in the context of cancer spread. This study aims to explore the potential involvement of PD-1 in the pathophysiology and progression of endometriosis. A total of 62 patients who under...
Immunological reference intervals in pregnancy
Ângelo-Dias, Miguel; Martins, Catarina Gregório; Mata, Mariana; Barata, Madalena; Chung, Ana; Sarzedas, Susana; Fernandes, Élia; Appleton, CláudiaBackground: Pregnancy induces profound immunological adaptations necessary to support fetal development while preserving maternal health. However, the systemic dynamics of less-studied adaptive immune cell subsets across gestation remain incompletely understood. Objective: We have conducted a comprehensive longitudinal analysis of peripheral B and T cell populations in healthy pregnant women in order to identif...
SARS-CoV-2 Infection in Children
Martins, Catarina Gregório; Ângelo-Dias, Miguel; Martins, Catarina; Chasqueira, Maria de Jesus; Brito, Maria João; Ângelo-Dias, MiguelChildren with COVID-19 typically experience milder symptoms and lower hospitalization rates, though severe cases do occur. Understanding age-related immune responses is crucial for future preparedness. We characterized immune response dynamics to SARS-CoV-2 in 145 samples from 119 pediatric patients (<18 years) with confirmed infection, assessed at four distinct time points: <14 days, 14 days-3 months, 3-6 mont...
Safety of fibrinogen concentrate in non-trauma and non-obstetric adult patients...
Gomes, Manuela; Ângelo-Dias, Miguel; S Duarte, Gonçalo; Dias, Sara Simões; Silvério Serra, Sofia; Lima, JorgeBackground: Low fibrinogen levels are associated with an increased risk of perioperative bleeding. However, there is an ongoing debate over the ideal treatment threshold, the benefits of prophylactic supplementation with fibrinogen concentrate, and the best source of fibrinogen. While fibrinogen concentrate supplementation is being widely used to treat bleeding related to acquired haemostatic deficiencies, ther...
Safety of Fibrinogen Concentrate for Correcting Perioperative Bleeding-Associat...
Gomes, Manuela; Ângelo-Dias, Miguel; Gomes, Manuela; Lima, Jorge; Ângelo-Dias, Miguel; Lima, JorgeBackground: Surgery often leads to bleeding associated with hypofibrinogenemia. Supplementation with fibrinogen concentrate appears to be effective and safe, although findings from studies are inconsistent. The primary aim of this study was to assess the safety of fibrinogen concentrate during the perioperative period. Methods: This single-centre, prospective, observational study included adult patients undergo...
The Role of NK and T Cells in Endometriosis
Reis, José Lourenço; Rosa, Natacha Nurdine; Reis, José; Martins, Catarina; Ângelo-Dias, Miguel; Rosa, Natacha Nurdine; Borrego, Luís Miguel; Lima, JorgeEndometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic endometrial cells from the immune system. Our research explores the immunological impact of endometriosis both locally and systemically, emphasizing natural killer (NK) and T...
B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatit...
Malheiro, Filipa; Ângelo-Dias, Miguel; Lopes, Teresa; Azeredo-Lopes, Sofia; Martins, Catarina; Borrego, Luis Miguel; BORREGO, LUIS MIGUELAcute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48 h after diagnosis. The Bedside Index of Severity in Acute Pancreatitis (BISAP) and length of hospital stay were also recorded. A healthy control (H...