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Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological an...

Sharifi-Rad, J; Quispe, C; Herrera-Bravo, J; Belén, LH; Kaur, R; Kregiel, D; Uprety, Y; Beyatli, A; Yeskaliyeva, B; Kirkin, C; Özçelik, B; Sen, S

The Glycyrrhiza genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammat...


Chemical Composition, Biological Activity, and Health-Promoting Effects of With...

Sharifi-Rad, J; Quispe, C; Ayatollahi, SA; Kobarfard, F; Staniak, M; Stepien, A; Czopek, K; Sen, S; Acharya, K; Matthews, KR; Sener, B; Devkota, HP

The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as...


Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism ...

Martins, N; Quispe, C; Kirkin, C; Senol, E; Zulug, A; Özçelik, B; Ademiluyi, AO; Oyeniran, OH; Semwal, P; Kumar, M; Sharopov, F; López, V; Les, F

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, lute...


Antioxidant, Antimicrobial, and Anticancer Effects of Anacardium Plants: An Eth...

Salehi, B; Gültekin-Özgüven, M; Kirkin, C; Özçelik, B; Morais-Braga, MFB; Carneiro, JNP; Bezerra, CF; Silva, TGd; Coutinho, HDM; Amina, B; Armstrong, L

Anacardium plants have received increasing recognition due to its nutritional and biological properties. A number of secondary metabolites are present in its leaves, fruits, and other parts of the plant. Among the diverse Anacardium plants' bioactive effects, their antioxidant, antimicrobial, and anticancer activities comprise those that have gained more attention. Thus, the present article aims to review the A...


Avocado–Soybean unsaponifiables: A panoply of potentialities to be exploited

Salehi, B; Rescigno, A; Dettori, T; Calina, D; Docea, AO; Singh, L; Cebeci, F; Özçelik, B; Bhia, M; Beirami, AD; Sharifi-Rad, J; Sharopov, F; Cho, WC

Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g....


Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardiop...

Sharifi-Rad, J; Rodrigues, CF; Sharopov, F; Docea, AO; Karaca, AC; Sharifi-Rad, M; Karincaoglu, DK; Gülseren, G; Senol, E; Demircan, E; Taheri, Y

Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumpti...


Anacardium plants: Chemical,nutritional composition and biotechnological applic...

Salehi, B; Gültekin-Özgüven, M; Kirkin, C; Özçelik, B; Morais-Braga, MFB; Carneiro, JNP; Bezerra, CF; Silva, TG; Coutinho, HDM; Amina, B; Armstrong, L

Anacardium plants are native to the American tropical regions, and Anacardium occidentale L. (cashew tree) is the most recognized species of the genus. These species contain rich secondary metabolites in their leaf and shoot powder, fruits and other parts that have shown diverse applications. This review describes the habitat and cultivation of Anacardium species, phytochemical and nutritional composition, and ...


Symphytum species: A comprehensive review on chemical composition, food applica...

Salehi, B; Sharopov, F; Tumer, TB; Ozleyen, A; Rodríguez-Pérez, C; Ezzat, SM; Azzini, E; Hosseinabadi, T; Butnariu, M; Sarac, I; Bostan, C; Acharya, K

Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling th...


Apium plants: Beyond simple food and phytopharmacological applications

Salehi, B; Venditti, A; Frezza, C; Yücetepe, A; Altuntas, Ü; Uluata, S; Butnariu, M; Sarac, I; Shaheen, S; Petropoulos, SA; Matthews, KR; Kiliç, CS

Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycos...


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