3 documents found, page 1 of 1
A unique serum IgG glycosylation signature predicts development of Crohn’s dise...
Gaifem, J; Rodrigues, CS; Petralia, F; Alves, I; Leite-Gomes, E; Cavadas, B; Dias, AM; Moreira-Barbosa, C; Revés, J; Laird, RM; Novokmet, M; Štambuk, JInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 y...
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulatio...
Pereira, MS; Durães, C; Catarino, TA; Costa, JL; Cleynen, I; Novokmet, M; Krištic, J; Štambuk, J; Conceição-Neto, N; Machado, JC; Marcos-Pinto, ROBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein, we evaluated whether MGAT5 SNPs might functionally impact on T cells glycosylation and plasma IgG gl...
Promoter methylation of the MGAT3 and BACH2 genes correlates with the compositi...
Klasic, M; Markulin, D; Vojta, A; Samaržija, I; Biruš, I; Dobrinic, P; Ventham, N; Trbojevic-Akmacic, I; Šimurina, M; Štambuk, J; Razdorov, GBackground: Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic changes and IBD. Independent GWA studies have identified genetic variants in the BACH2, IL6ST, LAMB1, IKZF1, and MGAT3 loci to be associated with both IBD and immunoglo...