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THE MOLECULAR MECHANISMS INVOLVED IN DOXORUBICIN-INDUCED SKELETAL MUSCLE WASTING
Moreira-Pais, Alexandra; Ferreira, Rita; Costa, Vera Marisa; A. Oliveira, Paula; A. Duarte, JoséChemotherapeutic agents like doxorubicin (DOX) are the foundation for the treatment of a variety of malignancies; however, these therapies have several side-effects. DOX may trigger or potentiate the muscle wasting observed in cancer patients, which is particularly worrying in frail old patients. Therefore, it is important to comprehend the mechanisms responsible for DOX-induced toxicity in skeletal muscle, to ...
Data: 2022
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Origem: Revista Portuguesa de Cirurgia