22 documents found, page 1 of 3
A review of conventional and emerging technologies for hydrogels sterilization
S. A. Bento, Cristiana; C. Gaspar, M.; Coimbra, Patrícia; de Sousa, Hermínio C.; E. M. Braga, MaraHydrogels are extensively used in the biomedical field, as drug delivery systems, wound dressings, contact lenses or as scaffolds for tissue engineering. Due to their polymeric nature and the presence of high amounts of water in their structure, hydrogels generally present high sensitivity to terminal sterilization. The establishment of an efficient sterilization protocol that does not compromise the functional...
Sustainable starch-based edible films with agrifood residues as potential carri...
Coimbra, Patrícia; Alarico, Susana; Empadinhas, Nuno; Braga, Mara E.M.; Gaspar, Marisa C.Edible films are promising carriers for probiotics and can be composed by agrifood residues, which are usually rich in polymers and bioactive compounds. In this work, starch-based films were enriched with three types of agrifood residues (quince, potato and orange peels) and the incorporation of the probiotic Lactobacillus rhamnosus was studied, as well as the addition of inulin as a protective prebiotic. The r...
Novel Oxygen- and Curcumin-Laden Ionic Liquid@Silica Nanocapsules for Enhanced ...
Henriques, Joana F.; Pina, João; Braga, Mara E. M.; Dias, Ana M. A.; Coimbra, Patrícia; Sousa, Herminio C. deThe efficiency of photodynamic therapy is often limited by the scarcity of oxygen at the target site. To address this problem, this work proposes the development of a new nanosystem for antimicrobial photodynamic therapy applications (aPDT) where the natural-origin photosensitizer curcumin (CUR) is immersed in an oxygen-rich environment. Inspired by the perfluorocarbon-based photosensitizer/O2 nanocarriers repo...
Comparative Analysis of Morphological and Release Profiles in Ocular Implants o...
Morais, Mariana; Coimbra, Patrícia; Pina, Maria E.The visual impairment that often leads to blindness causes a higher morbidity rate. The goal of this work is to create a novel biodegradable polymeric implant obtained from coaxial fibers containing the dispersed drug-acetazolamide-in order to achieve sustained drug release and increase patient compliance, which is of the highest importance. Firstly, during this work, uncoated implants were produced by electros...
Surface modification of an intraocular lens material by plasma-assisted graftin...
Vieira, A. Paula; Pimenta, Andreia F. R.; Silva, Diana; Gil, M. Helena; Alves, Patrícia; Coimbra, Patrícia; Mata, José L. G. C.; Bozukova, DimitriyaEndophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used...
Controlled release of moxifloxacin from intraocular lenses modified by Ar plasm...
Pimenta, Andreia; Vieira, Ana Paula; Colaco, Rogério; Saramago, Benilde; Gil, Maria; Coimbra, Patrícia; Alves, Patrícia; Bozukova, DimitriyaIntraocular lenses (IOLs) present an alternative for extended, local drug delivery in the prevention of post-operative acute endophthalmitis. In the present work, we modified the surface of a hydrophilic acrylic material, used for manufacturing of IOLs, through plasma-assisted grafting copolymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) or [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammo...
Coaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engi...
Coimbra, Patrícia; Santos, Patrícia; Alves, Patrícia; Miguel, Sónia P.; Carvalho, Marco António Paulo de; Sá, Kevin; Correia, Ilídio Joaquim SobreiraCoaxial electrospinning is a technique that allows the production of nanofibers with a core–shell structure. Such fibers present several advantages as materials for the preparation of scaffolds, namely due to the possibility of combining a core with the desired mechanical properties with a shell prepared from biocompatible materials that will establish proper interactions with the host. Herein, core-shell fibro...
Surface modification of an intraocular lens material by plasma-assisted graftin...
Vieira, Ana Paula; Pimenta, Andreia; Silva, Diana; Gil, Maria; Alves, Patrícia; Coimbra, Patrícia; Mata, Jose; Bozukova, Dimitriya; Correia, Tiago R.Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used...
Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fi...
Correia, Tiago R.; Ferreira, Paula; Vaz, Rita; Alves, Patrícia; Figueiredo, Margarida; Correia, Ilídio Joaquim Sobreira; Coimbra, PatríciaCardiovascular disease is the leading cause of morbidity and mortality among industrialized countries. Vascular grafts are often required for the surgical treatments. Considering the limitations associated with the use of autografts and with the currently available synthetic materials, a growing demand in tissue engineered vascular grafts has been registered. During the work here described, electrospinning tech...
Comparison of a xenogeneic and an alloplastic material used in dental implants ...
Figueiredo, Andreia; Coimbra, Patrícia; Cabrita, António; Guerra, Fernando; Figueiredo, MargaridaTwo commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface a...