4 documents found, page 1 of 1
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling
Domingues, Neuza S.; Catarino, Steve; Cristóvão, Beatriz; Rodrigues, Lisa; Carvalho, Filomena A; Sarmento, Maria João; Zuzarte, MónicaA robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair or lysophagy. Here we report exocytosis as a third response mechanism to lysosomal damage, which is further potentiated when membrane repair or lysosomal degradation mechanisms are impaired. We show that ...
Cx43-mediated sorting of miRNAs into extracellular vesicles
Martins-Marques, Tânia; Costa, Marina C; Catarino, Steve; Simões, Isaura; Aasen, Trond; Enguita, Francisco J; Girao, HenriqueThrough the exchange of lipids, proteins, and nucleic acids, extracellular vesicles (EV) allow for cell-cell communication across distant cells and tissues to regulate a wide range of physiological and pathological processes. Although some molecular mediators have been discovered, the mechanisms underlying the selective sorting of miRNAs into EV remain elusive. Previous studies demonstrated that connexin43 (Cx4...
Cx43‐mediated sorting of miRNAs into extracellular vesicles
Martins Marques, Tânia; Costa, Marina C.; Catarino, Steve; Simões, Isaura; Aasen, Trond; Enguita, Francisco J.; Girao, HenriqueThrough the exchange of lipids, proteins, and nucleic acids, extracellular vesicles (EV) allow for cell-cell communication across distant cells and tissues to regulate a wide range of physiological and pathological processes. Although some molecular mediators have been discovered, the mechanisms underlying the selective sorting of miRNAs into EV remain elusive. Previous studies demonstrated that connexin43 (Cx4...
Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Bre...
Tishchenko, Alexander; Azorín, Daniel D.; Vidal-Brime, Laia; Muñoz, María José; Arenas, Pol Jiménez; Pearce, Christopher; Girão, HenriqueConnexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms underlying these characteristics are not fully understood. Tunneling nanotubes (TNTs) are long and thin membrane projections that connect cells, facilitating the exchange of not only small molecules,...