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Refractory celiac disease type 2: how to diagnose and treat?
Soldera,Jonathan; Salgado,Karina; Pêgas,Karla LaisSUMMARY Refractory celiac disease is an uncommon condition which might be associated to poor prognosis. It is often treated with immunosuppressive medications, with poor results. It is divided in type 1 and type 2, the latter carrying a high risk for lymphoma and mortality. A case of a 41 year old female patient with refractory celiac disease type 2 is reported. She was treated with oral budesonide for six mont...
Pathogenesis, histopathologic findings and treatment modalities of lipoprotein ...
Cambruzzi,Eduardo; Pêgas,Karla LaisAbstract Lipoprotein glomerulopathy (LPG) is an uncommon cause of nephrotic syndrome and/or kidney failure. At microscopy, LPG is characterized by the presence of lipoprotein thrombi in dilated glomerular capillaries due to different ApoE mutations. ApoE gene is located on chromosome 19q13.2, and can be identified in almost all serum lipoproteins. ApoE works as a protective factor in atherosclerosis due its int...
Cancer: but what if it were a disease caused by an association between microorg...
Pêgas,Karla LaisABSTRACT Despite the advances in knowledge of the neoplasm behavior, the exact understanding of the biological processes that involve the malignant tumors is not yet fully elucidated. Mechanisms such as subversion of phagocytosis, cytokines and chemokines expression, blocking of immunity and apoptosis regulation are recognized ways of tumor survival. Several of these mechanisms are also used as survival strateg...
Aggressive papillary tumor of endolymphatic sac: case report of a rare neoplasia
Cambruzzi,Eduardo; Pêgas,Karla Lais; Almeida,Leandro P.; Perondi,Gerson Evandro; Dini,Leandro I.ABSTRACT Aggressive papillary endolymphatic sac tumor (ELST) is a rare neoplasm, occasionally related to von Hippel-Lindau disease, characterized by locally aggressive growth with temporal bone destruction. The authors report a case of ELST in a female patient exhibiting fifth through eighth cranial nerve paralysis. Computed tomography (CT) revealed a large lytic process involving the right temporal bone. The p...
Uma breve contextualização sobre a nefrite tubulo-intersticial por IgG4 com bas...
Pêgas,Karla Lais; Cambruzzi,Eduardo; Lobato,GiseleResumo A Doença relacionada a IgG4 (IgG4RD) é um processo inflamatório recente de etiologia supostamente autoimune, que se caracteriza por níveis séricos elevados de IgG4, um denso infiltrado mononuclear rico em plasmócitos IgG4 positivos e fibrose estoriforme. A nefrite túbulo-intersticial é a manifestação renal mais comum, com diferentes graus de disfunção renal e achados clínicos variáveis. Aqui, os autores ...
Renal mixed epithelial and stromal tumor: case report
Pêgas,Karla Lais; Cambruzzi,Eduardo; Furian,Roque D.; Hartmann,Antônio A.; Lamonatto,Suzana Elisabeth; Zanatta,Júlia M.; Guimarães,KáritaMixed epithelial and stromal tumor (MEST) represents a recently described biphasic kidney neoplasm, which predominantly affects perimenopausal females. The authors report the case of a young male patient with a MEST exhibiting positivity for estrogen and progesterone receptors. Computed tomography/magnetic resonance imaging (CT/MRI) showed an expansive lesion affecting the right kidney. Grossly, a solid-cystic ...
Relationship between the presence of liver metastases with histological grading...
Cambruzzi,Eduardo; Roman,Larissa R.; Noschang,Andressa A.; Pacheco,Fernanda B.; Gassen,Luana R.; Miranda,Luciana H.; Pêgas,Karla LaisABSTRACTIntroduction:Large intestine adenocarcinoma (LIA) is the most common cancer of the gastrointestinal tract, and corresponds to the fifth most common malignancy in Brazil. The main prognostic factors related to LIA are depth of tumor invasion and perivisceral lymph nodes status.Objective:To estimate the relationship between pathological findings and the presence of liver metastases (LM) in LIA cases.Metho...
Relationship between age and progesterone receptor expression with presence of ...
Cambruzzi,Eduardo; Gassen,Luana R.; Reginatto,Andrei; Noshang,Andressa; Brandão,Fernanda P.; Roman,Larissa R.; Miranda,Luciana H.; Pêgas,Karla LaisABSTRACTIntroduction:Breast invasive carcinoma of no special type (NST) is characterized by great morphological heterogeneity, and accounts for about 70%-80% of malignant breast tumors. The main prognostic factors are tumor size, degree of differentiation, and status of axillary lymph nodes. NST represents 15%-18% of central nervous system metastases (CNSm), and generally the response to systemic treatment/chem...
The relationship between serum levels of CA 125 and the degree of differentiati...
Cambruzzi,Eduardo; Lima,Rosane de; Teixeira,Simone Luís; Pêgas,Karla LaisIntroduction: Primary ovarian neoplasms exhibit a wide range of histopathological aspects, and tumors with epithelial differentiation are the most frequent. Among the malignant tumors, the most common histological type corresponds to serous adenocarcinoma, whose diagnosis is established in advanced stages of the disease in approximately 75% of the patients. Tumor marker CA 125 represents a glycoprotein synthesi...
Osseous metaplasia in gliosarcoma: an unusual histologic finding. Case report
Cambruzzi,Eduardo; Pêgas,Karla LaisGliosarcoma (GS) is a malignant neoplasm of the central nervous system that has coexisting glial and mesenchymal components. GSs are rarely related to osseous metaplasia. The authors report a case of GS in a male patient presenting apathy and catatonia. Computed tomography/magnetic resonance imaging showed an expansive process affecting the left frontal lobe. At microscopy, a malignant glioma constituted by hig...