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Correction to: The role of community pharmacists in managing common headache di...

Banihani, Heba; Lampl, Christian; Maassenvandenbrink, Antoinette; Amin, Faisal Mohammad; Carlsen, Louise Ninett; Coppola, Gianluca

Correction: J Headache Pain 26, 100 (2025) In this article, the text “on behalf of the European Headache Federation, the Norwegian Centre for Headache Research (NorHead) and Lifting The Burden: the Global Campaign against Headache” has been removed from the author list because it erroneously duplicated text from the article title.


The role of community pharmacists in managing common headache disorders, and th...

BaniHani, Heba; Lampl, Christian; MaassenvandenBrink, Antoinette; Amin, Faisal Mohammad; Carlsen, Louise Ninett; Coppola, Gianluca

In the sustainable development goals (SDG) context of seeking universal health coverage, the expanding gap between the supply of specialized and primary health-care providers of headache-related health care and the care needs of the very large number of people affected by headache is a formidable but not insoluble public-health challenge. Structured headache services provide a cost-effective framework wherein c...


The comparative effectiveness of migraine preventive drugs: a systematic review...

Lampl, Christian; Maassen van den Brink, Antoinette; Deligianni, Christina I.; Gil-Gouveia, Raquel; Jassal, Tanvir; Sanchez-Del-Rio, Margarita

OBJECTIVE: While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We conducted a systematic review and network meta-analysis to facilitate comparison between drugs for migraine prophylaxis. METHODS: We searched MEDLINE, EMBASE, CENTRAL, and clinicaltrials.gov from...


European Headache Federation (EHF) critical re-appraisal and meta-analysis of o...

Deligianni, Christina I.; Sacco, Simona; Ekizoglu, Esme; Uluduz, Derya; Gil-Gouveia, Raquel; MaassenVanDenBrink, Antoinette; Ornello, Raffaele

Objective: Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti-migraine drugs. In this systematic review and meta-analysis, we aimed to identify and rate the evidence for efficacy of flunarizine, a repurposed, first- or second-line treatment for migraine...


European Headache Federation (EHF) critical reappraisal and meta-analysis of or...

Raffaelli, Bianca; García-Azorín, David; Boucherie, Deirdre M.; Amin, Faisal Mohammad; Deligianni, Christina I.; Gil-Gouveia, Raquel; Kirsh, Sarah

Objective: Topiramate is a repurposed first-line treatment for migraine prophylaxis. The aim of this systematic review and meta-analysis is to critically re-appraise the existing evidence supporting the efficacy and tolerability of topiramate. Methods: A systematic search in MEDLINE, EMBASE, Cochrane CENTRAL, and ClinicalTrials.gov was performed for trials of pharmacological treatment in migraine prophylaxis as...


European Headache Federation (EHF) critical re-appraisal and meta-analysis of o...

Lampl, Christian; Versijpt, Jan; Amin, Faisal Mohammad; Deligianni, Christina I.; Gil-Gouveia, Raquel; Jassal, Tanvir; MaassenVanDenBrink, Antoinette

OBJECTIVE: The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis. METHODS: We report our methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA), by searching MEDLINE, EMBASE, Cochrane CENTRAL, and ClinicalTrials.gov for randomized trials of pharmacologic treatments for migraine prophylaxis. We included random...


European Headache Federation (EHF) consensus on the definition of effective tre...

Sacco, Simona; Lampl, Christian; Amin, Faisal Mohammad; Braschinsky, Mark; Deligianni, Christina; Uludüz, Derya; Versijpt, Jan; Ducros, Anne

BACKGROUND: Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. M...


European Headache Federation guideline on the use of monoclonal antibodies targ...

Sacco, Simona; Amin, Faisal Mohammad; Ashina, Messoud; Bendtsen, Lars; Deligianni, Christina I.; Gil-Gouveia, Raquel; Katsarava, Zaza

Background: A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world evidence have expanded the evidence and knowledge for those treatments. Therefore, the EHF panel decided to provide an updated guideline on the use of those t...


TBK1 mutation spectrum in an extended European patient cohort with frontotempor...

van der Zee, Julie; Gijselinck, Ilse; Van Mossevelde, Sara; Perrone, Federica; Dillen, Lubina; Heeman, Bavo; Bäumer, Veerle; Engelborghs, Sebastiaan

We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated phenotypic spectrum by exonic resequencing of TBK1 in a cohort of 2,538 patients with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or FTD plus ALS, ascertained within the European Early-Onset Dementia Consortium. We assessed pathogenicity of predicted protein-truncating mutations by measuring...


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