40 documents found, page 1 of 4
Interplay between western diet and mammary cancer: data from a chemically-induc...
Silva, J; Azevedo, T; Aires, I; Peixoto, F; Neuparth, MJ; Faustino-Rocha, AI; Duarte, JA; Oliveira, PABackground/Aim: This study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N- nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), a...
Mammary cancer models: an overview from the past to the future
Silva, J; Oliveira, PA; Duarte, JA; Faustino-Rocha, AIAbstract. Breast cancer research heavily relies on diverse model systems to comprehend disease progression, develop novel diagnostics, and evaluate new therapeutic strategies. This review offers a comprehensive overview of mammary cancer models, covering both ex vivo and in vivo approaches. We delve into established techniques, such as cell culture and explore cutting-edge advancements, like tumor-on-a-chip and...
Effects of ladder-climbing exercise on mammary cancer: data from a chemically i...
Silva, J; Azevedo, T; Faustino-Rocha, AI; Oliveira, PA; Duarte, JABreast cancer is a major health concern for both humans and companion animals, particularly female dogs and cats. This study explores whether resistance training can influence the development of mammary cancer in female rats. The rats were divided into four groups, including those that exercised by climbing a ladder with increasing weight three times a week for 18 weeks. At the end of the study, tumor developme...
The impact of a Western diet and resistance training in a rat model of mammary ...
Silva, J; Azevedo, T; Faustino-Rocha AI; Duarte, JA; Oliveira, PAThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
Long-term exposure to supraphysiological levels of testosterone impacts rat sub...
Valente-Santos, J; Vitorino, R; Sousa-Mendes, C; Oliveira, Paula; Colaço, B; Faustino-Rocha, Ana; Neuparth, MJ; Leite-Moreira, A; Duarte, JAThe salivary glands play a central role in the secretion of saliva, whose composition and volume affect oral and overall health. A lesser-explored dimension encompasses the possible changes in salivary gland proteomes in response to fluctuations in sex hormone levels. This study aimed to examine the effects of chronic exposure to testosterone on salivary gland remodeling, particularly focusing on proteomic adap...
Realistic aspects behind the application of the rat model of mammary cancer che...
Silva, J; Faustino-Rocha, Ana I; Duarte, JA; Oliveira, PACancer is one of the most important public health problems worldwide. Despite the great contribution of in-vitro studies for biomedical research, animals are essential to study diseases’ biopathology and diagnosis, and searching for new preventive and therapeutic strategies. Breast cancer is currently the most common cancer globally, accounting for 12.5% of all new annual cancer cases worldwide. Although the ra...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, DThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Evaluating the impact of a western diet on biochemical parameters in an animal ...
Silva, A; Azevedo, T; Anjos, L; Faustino-Rocha, Ana I; Oliveira, Paula A; Duarte, JABreast cancer continues to affect millions of individuals worldwide. In this way, it is of paramount importance to understand the effects of dietary choices in this disease development. This work aimed to evaluate the influence of Western diet (WD) on biochemical parameters in an animal model of breast cancer. Twenty-eight female Wistar rats were divided into four groups (n=7): WD; WD+N-methyl- N-nitrosourea (M...
Mammary tumors incidence: a comparison between three studies carried out in fem...
Silva, J; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JAIntroduction: Breast cancer is still one of the most frequent malignancies among women. The mammary lesions induced by the carcinogen N-methyl-N-nitrosourea (MNU) are remarkably comparable to those observed in women. This work aimed to compare the mammary cancer incidence in female rats exposed to MNU in three different experimental protocols, envisioning to study mammary cancer development and progression. Mat...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMaterial & Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced sedentary (SED+PCa; n=15), and induced exercised (EX+PCa; n=20). Exercised animals were trained in a treadmill, for 53 weeks. PCa induction consisted of flutamide and N-methyl-N-nitrosourea administration, followed by testosterone propionate implants. At sacrifice, pr...