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Global, regional, and national prevalence of adult overweight and obesity, 1990...

GBD 2021 Adult BMI; Ng, Marie; Gakidou, Emmanuela; Lo, Justin; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbas, Nasir; Abbasian, Mohammadreza

Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050. Methods Leveraging established methodology from the Glob...


Global, regional, and national age-specific progress towards the 2020 milestone...

GBD 2021 Tuberculosis Collaborators; Ledesma, Jorge R.; Ma, Jianing; Zhang, Meixin; Basting, Ann V.L.; Chu, Huong Thi; Vongpradith, Avina

Background: Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to 2021, and to report on age-specific progress between 2015 and 2...


Global burden and strength of evidence for 88 risk factors in 204 countries and...

GBD 2021 Risk Factors Collaborators; Brauer, Michael; Roth, Gregory A.; Aravkin, Aleksandr Y.; Zheng, Peng; Abate, Kalkidan Hassen

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attr...


Global, regional, and national burden of disorders affecting the nervous system...

GBD 2021 Nervous System Disorders Collaborators; Steinmetz, Jaimie D.; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurode...


Global burden of chronic respiratory diseases and risk factors, 1990-2019: an u...

Momtazmanesh, Sara; Moghaddam, Sahar Saeedi; Ghamari, Seyyed-Hadi; Rad, Elaheh Malakan; Rezaei, Negar; Shobeiri, Parnian; Aali, Amirali

Background Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods Using...


Global, regional, and national burden of diabetes from 1990 to 2021, with proje...

Ong, Kanyin Liane; Stafford, Lauryn K.; McLaughlin, Susan A.; Boyko, Edward J.; Vollset, Stein Emil; Smith, Amanda E.; Dalton, Bronte E.; Duprey, Joe

Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of ty...


Global, regional, and national incidence of six major immune-mediated inflammat...

GBD 2019 IMID Collaborators; Wu, Dongze; Jin, Yingzhao; Xing, Yuhan; Abate, Melsew Dagne; Abbasian, Mohammadreza; Abbasi-Kangevari, Mohsen

Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, an...


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