15 documents found, page 1 of 2
Access to paediatric cardiac surgical care for congenital heart diseases in low...
Mendes, Vitor; Tsishkovska, Marina; Pereira, Telmo; Abecasis, AnaIntroduction: Congenital heart diseases are one of the leading causes of children mortality worldwide. Due to inadequate access to paediatric cardiac surgical care, the burden of these anomalies is even higher in low and middle-low-income countries. Objective: To comprehensively describe the access to paediatric cardiac surgical care in low and middle-low-income countries, highlighting existing disparities and ...
Características demográficas relacionadas com a infeção pelo HBV em dadores de ...
S. Sebastião, Cruz; Vigário, António; Jandondo, Domingos; Vienga, Pedro; Sebastião, Joana; Comandante, Felicia; Sacomboio, Euclides; Pimentel, VictorIntrodução: O vírus da hepatite B (HBV) constitui um grave problema de saúde pública global, especialmente em países de baixa e média renda. Globalmente, mais de 2 bilhões de pessoas, o equivalente a cerca de um terço da população mundial, já foram infetados com HBV, dos quais 350 milhões desenvolveram infeção crônica (André, 2000). Atualmente, o HBV é considerado um dos principais fatores de desenvolvimento de...
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...
Pingarilho, Marta; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca Branco; Piñeiro, Carmela; Koch, CarmoObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Phylogeography of hepatitis B virus: the role of Portugal in the early dissemin...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
HIV-1-transmitted drug resistance and transmission clusters in newly diagnosed ...
Pingarilho, Marta; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca Branco; Piñeiro, Carmela; Koch, CarmoObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Phylogeography of hepatitis B virus : the role of Portugal in the early dissemi...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
Molecular epidemiology of HIV-1 infected migrants followed up in Portugal: tren...
Pimentel, Victor; Pingarilho, Marta; Alves, Daniela; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, Andrea-Clemencia; Libin, PieterMigration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as ...
A computational method for the identification of Dengue, Zika and Chikungunya v...
Fonseca, Vagner; Libin, Pieter J. K; Theys, Kristof; Faria, Nuno R; Nunes, M?rcio Roberto Teixeira; Restovic, Maria I; Freire, Murilo; Giovanetti, MartaSupported by a research Flagship grant from the South African Medical Re-search Council (MRC-RFA-UFSP-01-2013/UKZN HIVEPI), a Royal Society Newton Advanced Fellowship (TdO), the VIROGENESIS project receives funding from the European Union?s Horizon 2020 Research and Innovation Programme (under Grant Agreement no. 634650) and the National Institutes of Health Common Fund, grant number U24HG006941. Pieter Libin w...
Accidental father-to-son HIV-1 transmission during the seroconversion period
Ezeonwumelu, Ifeanyi; Bártolo, Inês; Martin, Francisco; Abecasis, Ana; Campos, Teresa; Romero-Severson, Ethan O.; Leitner, Thomas; Taveira, NunoA 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about...
Donor-Recipient identification in para- and poly-phyletic trees under alternati...
Romero-Severson, Ethan O.; Bulla, Ingo; Hengartner, Nick; Bártolo, Inês; Abecasis, Ana; Azevedo-Pereira, José M.; Taveira, Nuno; Leitner, ThomasDiversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections, there is clear evidence for multiple founding variants, which can influence the efficacy of putative prevention methods, and the reconstruction of epidemiologic histories. To infer who-infected-whom, and to co...