23 documents found, page 1 of 3
Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HI...
Sebastião, Cruz S.; Pimentel, Victor; Jandondo, Domingos; Sebastião, Joana M. K.; Sacomboio, Euclides; Pingarilho, Marta; Brito, MiguelBackground: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3'A in HIV-infected and uninfected individuals in Luanda, the capital o...
Determinants of HIV-1 transmission clusters and transmitted drug resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N. S.; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIn the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM new...
Sociodemographic, Clinical, and Behavioral Factors Associated with Sexual Trans...
Miranda, Mafalda N. S.; Pimentel, Victor; Graça, Jacqueline; Seabra, Sofia G.; Sebastião, Cruz S.; Diniz, António; Faria, Domitília; Teófilo, EugénioIntroduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with an increased risk of acquiring HIV infection. Migrants are reportedly highly affected by STIs. Objectives: This study aims to characterize factors associated with ...
Determinants of HIV late presentation among men who have sex with men in Portug...
Abrantes, Ricardo; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca; Piñeiro, Carmela; Koch, CarmoIntroduction: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral q...
HIV-1 diversity and pre-treatment drug resistance in the era of integrase inhib...
Sebastião, Cruz S.; Abecasis, Ana B.; Jandondo, Domingos; Sebastião, Joana M.; Vigário, João; Comandante, Felícia; Pingarilho, Marta; Pocongo, BárbaraThe surveillance of drug resistance in the HIV-1 naïve population remains critical to optimizing the effectiveness of antiretroviral therapy (ART), mainly in the era of integrase strand transfer inhibitor (INSTI) regimens. Currently, there is no data regarding resistance to INSTI in Angola since Dolutegravir-DTG was included in the first-line ART regimen. Herein, we investigated the HIV-1 genetic diversity and ...
Determinants of HIV late presentation among men who have sex with men in Portug...
Abrantes, Ricardo; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca; Piñeiro, Carmela; Koch, CarmoIntroduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019.Methods We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral ques...
Sociodemographic, clinical, and behavioral factors associated with sexual trans...
Miranda, Mafalda N. S.; Pimentel, Victor; Graça, Jacqueline; Seabra, Sofia G.; Sebastião, Cruz S.; Diniz, António; Faria, Domitília; Teófilo, EugénioIntroduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with an increased risk of acquiring HIV infection. Migrants are reportedly highly affected by STIs. Objectives: This study aims to characterize factors associated with ...
Differential patterns of postmigration HIV-1 infection acquisition among Portug...
Pimentel, Victor Figueiredo; Pingarilho, Marta; Sole, Giordano; Alves, Daniela; Miranda, Mafalda; Diogo, Isabel; Fernandes, Sandra; Pineda-Pena, AndreaObjective: To investigate the dynamics of phylogenetic transmission clusters involving immigrants of Portuguese Speaking Countries living in Portugal. Design/methods: We included genomic sequences, sociodemographic and clinical data from 772 HIV migrants followed in Portugal between 2001 and 2017. To reconstruct HIV-1 transmission clusters, we applied phylogenetic inference from 16 454 patients: 772 migrants, 2...
Tracing the impact of public health interventions on HIV-1 transmission in Port...
Vasylyeva, Tetyana I.; Plessis, Louis du; Pineda-Peña, Andrea C.; Kühnert, Denise; Lemey, Philippe; Vandamme, Anne-Mieke; Gomes, PerpétuaBackground Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. Methods Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific ef...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M. M.; Carvalho, Alexandre; Pingarilho, Marta; Abecasis, Ana B.; Osório, Nuno S.; Rodrigues, Fernando; Ramos, Helena; Neves, IsabelHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...