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The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A System...

Soares, S; Susana Guerreiro; Cruz Martins, N; Faria, I; Baylina, P; Sales, MG; Correa Duarte, MA; Fernandes, R

In the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA ...


Vitamin A enhances macrophages activity against B16-F10 malignant melanocytes: ...

Oliveira, S; Costa, J; Faria, I; Guerreiro, SG; Fernandes, R

Background and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and inve...


Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: ...

Oliveira, S; Costa, J; Faria, I; Susana Guerreiro; Fernandes, R

Background and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and inve...


Cytotoxic and Genotoxic Effects of Environmental Relevant Concentrations of Bis...

Ramos, C; Ladeira, C; Zeferino, S; Dias, A; Faria, I; Cristovam, E; Gomes, M; Ribeiro, E

Bisphenol A (BPA) is one of the most widely utilized endocrine disruptors to which humans are exposed, particularity through ingestion. BPA is an aneugenic compound with a putative association to tumorigenesis. Although extensively studied in estrogen responsive cells, information regarding its effects on cells from the upper gastrointestinal tract exposed to free/active forms of BPA is still scarce. Similarly,...


Portal Vein Embolization With N-Butyl-Cyanoacrylate Through an Ipsilateral Appr...

Mendes Luz, JH; Mendes Luz, P; Bilhim, T; Martin, H; Gouveia, H; Coimbra, E; Veloso Gomes, F; Souza, R; Faria, I; Nepomuceno de Miranda, T

PURPOSE: To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and patient outcome. METHODS: Over a 5-year period 50 non-cirrhotic consecutive patients were included with primary or secondary liver cancer treatable by hepatectomy with a liver remnant (FLR) volume...


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